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首页> 外文期刊>Biomaterials Science >Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes
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Green facile synthesis to develop nanoscale coordination polymers as lysosome-targetable luminescent bioprobes

机译：绿色容纳合成以开发纳米级配位聚合物作为溶酶体靶向亮度生物软管

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Three new coordination polymers (CPs), namely [{M(HL)(L)(H2O)}(ClO4)(H2O)](infinity) (M = Zn for CP 1, Mn for CP 2, Cu for CP 3) were synthesized to explore their efficacy as lysosome-targetable luminescent bioprobes. The synthesized CPs were characterized by techniques including single-crystal X-ray analysis, FTIR spectroscopy and elemental analysis. Single-crystal analysis revealed the formation of iso-structural CPs displaying distorted adamantoid topology developed by bridging ligands and H-bonds connections and metals at the nodes. A green hand-grinding technique with a mortar and pestle resulted in nanoscale coordination polymers (NCPs) suitable for cell permeability and was further confirmed by SEM and DLS analyses. Two of these hand-ground nanoscale coordination polymers NCP 1 and NCP 2 showed excellent green luminescence and were explored as potential and selective long-time biotrackers towards lysosome using the human lung carcinoma cell line (A549). Strikingly, the developed bioprobe displayed excellent bio-availability, photostability and excellent selectivity towards lysosomes sustained by various in vitro cell imaging experiments. Moreover, the long-term probing ability of these NCPs turned out to be better than the commercially available lysosome tracker i.e. LysoTracker Red, indicating their potential real-life application in bio-imaging. To the best ofour knowledge, this is the first example of nonexpensive and less toxic essential transition metal-based nanoscale coordination polymers that can behave as effective lysosome-targetable luminescent bioprobes.
机译：三种新的配位聚合物（CPS），即[{M（HL）（L）（H2O）（CLO 4）（CLO 4）（H 2 O）]（Infinity）（M = CP 1的M = Zn，CP 2的MN，CP 3的CP 3）合成以探讨它们作为溶酶体靶向亮度生物切进剂的疗效。通过包括单晶X射线分析，FTIR光谱和元素分析的技术表征合成的CPS。单晶分析显示，通过在节点上桥接配体和H键合连接和金属，形成肌肤结构CPS的形成扭曲的小马拓扑。具有砂浆和杵的绿色手工研磨技术导致适用于细胞渗透性的纳米级配位聚合物（NCPS），并通过SEM和DLS分析进一步证实。这些手工纳米级配位聚合物NCP 1和NCP 2中的两种显示出优异的绿色发光，并且使用人肺癌细胞系（A549）探讨了朝向溶酶体的潜在和选择性的长时间生物载体。引人注目的是，发育的生物对比表现出优异的生物可用性，光稳定性和对溶酶体的优异选择性，其在各种体外细胞成像实验中持续。此外，这些NCP的长期探测能力结果比市售的溶酶体跟踪器更好，即Lysotracker Red，表明它们在生物成像中的潜在真实应用。为了最好的知识，这是一种非激烈且毒性较小的基本过渡金属的纳米级配位聚合物的第一例，其可以表现为有效的溶酶体可靶向发光生物体。

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