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A multifunctional shape-adaptive and biodegradable hydrogel with hemorrhage control and broad-spectrum antimicrobial activity for wound healing

机译：具有出血控制的多功能形状 - 适应性和可生物降解的水凝胶和伤口愈合的广谱抗微生物活性

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摘要

Hemorrhage is the leading cause of preventable death of injured military and civilian patients, and subsequent infection risks endanger their lives or impede the healing of their wounds. Here, we report an injectable biodegradable hydrogel with hemostatic, antimicrobial, and healing-promoting properties. The hydrogel was prepared by dynamic cross-linking of a natural polysaccharide (dextran) with antimicrobial peptide ε-poly-L-lysine (EPL) and encapsulating base fibroblast growth factor (bFGF). The amino groups of EPL were allowed to react with the aldehyde of oxidized dextran (OD) through the Schiff-base reaction for the generation of hydrogels that have fast self-healing and injectable characteristics and adapt to the shapes of wounds. The prepared OD/EPL hydrogels promoted blood clotting in vitro and stopped bleeding in a rat liver injury model within 6 min through their platelet-aggregating ability and sealing effect. These hydrogels exhibited inherent antimicrobial effects without the use of antibiotics and effectively killed a broad spectrum of pathogenic microbes, including Gram-positive methicillin-resistant Staphylococcus aureus (MRSA), Gram-negative Escherichia coli, and Pseudomonas aeruginosa and fungus Candida albicans in vitro. Moreover, these OD/EPL hydrogels were compatible with mammalian cells in vitro and in vivo and biodegradable in the mouse body. The loaded bFGF can be released sustainably, and it can promote angiogenesis, endothelial cell migration, and consequently accelerate the healing of wounds. The OD/EPL hydrogel inhibited MRSA infection in a rat full-thickness skin wound model and promoted healing. This kind of multifunctional hydrogel is a promising wound dressing for the emergency treatment of acute deep or penetrating injuries.
机译：出血是受伤军事和平民患者预防死亡的主要原因，随后的感染风险危及他们的生命或阻碍伤口的愈合。在这里，我们报告了一种具有止血，抗微生物和愈合促进性能的可注射的可生物降解的水凝胶。通过用抗微生物肽ε-聚-L-赖氨酸（EPL）和包封基纤维细胞生长因子（BFGF）的天然多糖（葡聚糖）的动态交联制备水凝胶。允许EPL的氨基与氧化葡聚糖（OD）的醛反应通过Schiff-Base反应，用于产生具有快速自愈合和可注射特性的水凝胶，并适应伤口的形状。制备的OD / EPL水凝胶在体外促进血液凝固，并通过其血小板聚集能力和密封效果在6分钟内在大鼠肝损伤模型中渗出。这些水凝胶表现出固有的抗微生物效应而不使用抗生素，有效地杀死了广谱的致病微生物，包括革兰氏甲氧西蛋白抗性金黄色葡萄球菌（MRSA），革兰氏阴性大肠杆菌和假单胞菌铜绿假单胞菌在体外，铜绿假单胞菌和真菌念珠菌蛋白质。此外，这些OD / EPL水凝胶与体外和体内哺乳动物细胞相容，并在小鼠体内生物降解。加载的BFGF可以可持续释放，可以促进血管生成，内皮细胞迁移，并因此加速伤口的愈合。 OD / EPL水凝胶在大鼠全厚皮肤伤口模型中抑制MRSA感染并促进愈合。这种多功能水凝胶是一种有前途的伤口敷料，用于急性深层或渗透伤害的紧急治疗。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共16页
  • 作者

    Lingling Gao; Jingjie Chen; Wei Feng; Qing Song; Jingjing Huo; Luofeng Yu; Nian Liu; Tengjiao Wang; Peng Li; Wei Huang;

  • 作者单位

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

    Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &

    Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) 127 West Youyi Road Xi'an 710072 Chin;

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

    Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &

    Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) 127 West Youyi Road Xi'an 710072 Chin;

    Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &

    Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) 127 West Youyi Road Xi'an 710072 Chin;

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

    Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &

    Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU) 127 West Youyi Road Xi'an 710072 Chin;

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

    Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University Nanjing 211816 China;

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  • 正文语种 eng
  • 中图分类 计量学;
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