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首页> 外文期刊>Biomaterials Science >Intradermal administration of green synthesized nanosilver (NS) through film-coated PEGDA microneedles for potential antibacterial applications
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Intradermal administration of green synthesized nanosilver (NS) through film-coated PEGDA microneedles for potential antibacterial applications

机译：通过膜涂覆的PEGDA微针来施用绿色合成纳米ilm（NS）的皮内给药，用于潜在的抗菌应用

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摘要

Skin infections caused by pathogens, including bacteria, fungi and viruses, are difficult to completely eliminate through standard topical administration, owing to the restricted drug permeation into the epidermis layer. Herein, we developed a poly(ethylene glycol) diacrylate (PEGDA) microneedle patch with surface coating of a nanosilver (NS) encapsulated gelatin/sucrose film for antibacterial applications, by virtue of enhanced skin permeation by microneedle penetration and efficient drug delivery through rapid film dissolving. NS was facilely synthesized through a green process based on the bioinspired crystallization of ionic state silver in the presence of a silk fibroin (SF) template. A gelatin/sucrose polymeric film encapsulating NS was dressed on the surface of the mold cavity, and film-coated PEGDA (PEGDA/film-NS) microneedles were subsequently fabricated through standard ultraviolet (UV) light-induced polymerization. To demonstrate their advantages for therapeutic applications, the physicochemical properties of the as-developed microneedles were characterized in terms of their morphology, composition, mechanical strength, etc. Moreover, rapid NS release from PEGDA@film-NS microneedles driven by the aqueous environment was demonstrated under physiological conditions. Additionally, such film-coated microneedles exhibited good mechanical strength for skin penetration, and their antibacterial activity against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus aureus) as well as Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) was verified using bacterial suspension in vitro. Altogether, such a minimally invasive strategy exhibited good potential for realizing a broad-spectrum antibacterial effect, which may provide a practical methodology for the management of polymicrobial skin infection during clinical trials.
机译：由于限制的药物渗透到表皮层，难以通过标准局部给药难以完全消除皮肤感染，包括细菌，真菌和病毒。在此，我们开发了一种聚（乙二醇）二丙烯酸酯（PEGDA）微针（PEGDA）微针（PEGDA）微针贴片，其具有用于抗菌应用的纳米ilm（NS）包封的明胶/蔗糖膜，用于通过快速膜通过微针穿透和有效的药物递送的增强的皮肤渗透，具有增强的皮肤渗透溶解。基于在丝素蛋白（SF）模板存在下，通过基于离子态银的生物透明结晶，通过绿色工艺合成NS。将胶囊/蔗糖聚合物薄膜包装在模腔的表面上，随后通过标准紫外（UV）光诱导的聚合来制造薄膜涂覆的PEGDA（PEGDA /薄膜-NS）微针。为了证明其对治疗应用的优点，在其形态，组成，机械强度等方面表征了原发性微针的物理化学性质。此外，通过由含水环境驱动的PEGDA @薄膜NS微针释放的快速NS释放在生理条件下证明。另外，这种薄膜涂覆的微针验证了皮肤渗透的良好机械强度，并使用细菌悬浮液验证了对革兰氏阳性细菌（金葡萄球菌和金黄色葡萄球菌）以及革兰阴性细菌（大肠杆菌和假单胞菌）的抗菌活性体外。完全，这种微创策略具有实现广谱抗菌效应的良好潜力，这可以为临床试验期间提供多种状体皮肤感染的实用方法。

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  • 来源
    《Biomaterials Science》 |2021年第6期|共11页
  • 作者

    Gao Ya; Zhang Wei; Cheng Yan Fang; Cao Yang; Xu Zhigang; Xu Li Qun; Kang Yuejun; Xue Peng;

  • 作者单位

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 2 Inst Ultrasound Imaging Chongqing Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 2 Inst Ultrasound Imaging Chongqing Key Lab Ultrasound Mol Imaging Chongqing 400010 Peoples R China;

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

    Southwest Univ Sch Mat &

    Energy Chongqing 400715 Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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