Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy

Kim Sungyun; Seo Ji-Hye; Jeong Da In; Yang Mingyu; Lee Song Yi; Lee Junmin; Cho Hyun-Jong

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Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy

机译：芬顿的反应，谷胱甘肽还原，并通过铜硫酸酯交联的谷胱甘肽烧蚀内置水凝胶，用于基因酯硫酸盐 - 区域癌症治疗

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Fenton-like reaction-associated chemodynamic therapy (CDT) and hyperthermia-inducing photothermal therapy (PTT)-combined crosslinked hydrogel systems were developed for loco-regional cancer therapy. Cupric sulfate (Cu) has been employed to crosslink the catechol-functionalized hyaluronic acid (HC) polymer-based gel via metal-catechol coordination and covalent bonding of the catechol group (by pH adjustment). Cu can also be used as a hydroxyl radical-generating agent with endogenous H2O2 in cancer cells mediated by Fenton-like reaction and it can reduce intracellular glutathione (GSH) levels leading to the inhibition of reactive oxygen species (ROS) scavenging. These two strategies can amplify the ROS-initiated CDT efficiency for combating cancer. The Cu-incorporated crosslinked hydrogel structure with pH modulation was appropriate for injectable gel formation via a single syringe. The incorporation of indocyanine green (ICG) into the hydrogel network and near-infrared (NIR) laser irradiation provided a temperature elevation sufficient for induction of hyperthermia in cancer therapy. It is expected that the designed HC/Cu/ICG hydrogel can be used safely and efficiently for local CDT and PTT of breast cancer.

机译：芬顿的反应相关的化学动力学治疗（CDT）和热疗诱导的光热疗（PTT） - 组合的交联水凝胶系统用于基因群癌症治疗。已采用硫酸铜（Cu）通过金属 - 儿茶酚协调和儿茶酚基团（通过pH调节）的金属 - 儿茶酚协调和共价键来交联。 Cu也可以用作羟基自由基发生剂，其具有内源性H 2 O 2在由Fenton样反应介导的癌细胞中，它可以减少细胞内的谷胱甘肽（GSH）水平，导致反应性氧物种（ROS）清除的抑制作用。这两种策略可以扩增ROS-发起的CDT效率来对抗癌症。具有pH调节的Cu的交联水凝胶结构适合于通过单个注射器的可注射凝胶形成。将吲哚菁绿（ICG）掺入水凝胶网络和近红外（NIR）激光照射提供了一种足以诱导癌症治疗中热疗的温度升高。预计设计的HC / Cu / ICG水凝胶可以安全有效地用于局部CDT和乳腺癌PTT。

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来源
《Biomaterials Science》 |2021年第3期|共14页
作者
Kim Sungyun; Seo Ji-Hye; Jeong Da In; Yang Mingyu; Lee Song Yi; Lee Junmin; Cho Hyun-Jong;
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Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

Kangwon Natl Univ Coll Pharm Chunchon 24341 Gangwon South Korea;

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正文语种 eng
中图分类分子生物学;
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Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy

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