Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides SI and S2

Christopher E.Jones; Claire B. Otara; Nadine D. Younan; John H. Viles; Maurice R. Elphick

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Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides SI and S2

机译：海星SALMFamide神经肽SI和S2嵌合类似物的生物活性和结构特性

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School of Biological & Chemical Sciences, Queen Mary University of London, Mile End Road, London El 4NS, UK The SALMFamides are a family of neuropeptides that occur in species belonging to the phylum Echinodermata (e.g. starfish, sea cucumbers, sea urchins). There are two types of SALMFamides-L-type, which have the C-terminal motif SxLxFamide (where x is variable), and F-type, which have the C-terminal motif SxFxFamide. Furthermore, analysis of the pharmacological actions of SALMFamides has revealed that both L-type and F-type SALMFamides cause muscle relaxation in echinoderms [1,2].

机译：伦敦女王玛丽大学生物与化学科学学院，英国伦敦El 4NS英里尾路SALMFamides是一类神经肽家族，存在于棘皮动物门属物种（例如海星，海参，海胆）中。 SALMFamides有两种类型：具有C端基序SxLxFamide（其中x可变）的LAL型和具有C端基序SxFxFamide的F型。此外，对SALMFamides的药理作用的分析表明，L型和F型SALMFamides均可引起棘皮动物肌肉松弛[1,2]。

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《Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics》 |2014年第10期|共9页
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Christopher E.Jones; Claire B. Otara; Nadine D. Younan; John H. Viles; Maurice R. Elphick;
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1. Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides SI and S2 [J] . Christopher E.Jones, Claire B. Otara, Nadine D. Younan, Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2014,第10期

机译：海星SALMFamide神经肽SI和S2嵌合类似物的生物活性和结构特性
2. TISSUE DISTRIBUTION OF THE SALMFAMIDE NEUROPEPTIDES S1 AND S2 IN THE STARFISH ASTERIAS RUBENS USING NOVEL MONOCLONAL AND POLYCLONAL ANTIBODIES .2. DIGESTIVE SYSTEM [J] . Newman SJ., Thorndyke MC., Elphick MR. The Royal Society Proceedings B: Biological Sciences . 1995,第1361期

机译：使用新颖的单克隆和多克隆抗体，在星形胶质星形胶质细胞中S1和S2的神经酰胺S2和S2的组织分布。2。消化系统
3. Tissue distribution of the SALMFamide neuropeptides S1 and S2 in the starfish Asterias rubens using novel monoclonal and polyclonal antibodies. I. Nervous and locomotory systems. [J] . Newman SJ, Elphick MR, Thorndyke MC The Royal Society Proceedings B: Biological Sciences . 1995,第1360期

机译：使用新型单克隆抗体和多克隆抗体，SALMFamide神经肽S1和S2在海星红豆中的组织分布。 I.神经系统和机车系统。
4. Synthesis and Biological Activities of Chimeric Bioactive Peptides Based on Amino Acids Coupled to 4-Anilino-N-Phenethyl- Piperidine [C] . Ravil R. Petrov, Ruben S. Vardanyan, Shou-wu Ma American Peptide Symposium . 2006

机译：基于氨基酸的嵌合生物活性肽的合成和生物活性偶联至4-苯基-N-苯乙烯 - 哌啶
5. Part I. Application of 2-hydroxymethylacrylic acid, a product of Baylis-Hillman reaction, for the synthesis of novel N-backbone-to-side-chain cyclic peptide analogs: Strategies and side reactions. Part II. Synthesis and biological activities of chimeric bioactive peptides featuring amino acids coupled to 4-anilino-n-phenethyl-piperidine. [D] . Petrov, Ravil Rashitovich. 2007

机译：第一部分。Baylis-Hillman反应产物2-羟甲基丙烯酸在合成新型N骨架至侧链环状肽类似物中的应用：策略和副反应。第二部分具有与4-苯胺基-n-苯乙基-哌啶偶联的氨基酸的嵌合生物活性肽的合成和生物活性。
6. SALMFamide neuropeptides cause relaxation and eversion of the cardiac stomach in starfish [O] . R. Melarange, D. J. Potton, M. C. Thorndyke, 1999

机译：SALMFamide神经肽导致海星心脏胃部松弛和外翻
7. Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2. [O] . Jones, CE, Otara, CB, Younan, ND, 2014

机译：海星SALMFamide神经肽S1和S2嵌合类似物的生物活性和结构特性。
8. Beta-Amino Acid Analogs of an Insect Neuropeptide Feature Potent Bioactivity and Resistance to Peptidase Hydrolysis [R] . Zubrzak, P., Williams, H., Coast, G. M., 2006

机译：昆虫神经肽的β-氨基酸类似物具有强效生物活性和对肽酶水解的抗性

Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides SI and S2

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