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首页> 外文期刊>Cell metabolism >Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
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Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes

机译：二甲双胍与Covid-19和预先存在的2型糖尿病中的酸中毒的发病率较高，但不死亡率

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摘要

The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19.
机译：糖尿病2019冠状病毒疾病和T2D患者的血糖控制对糖尿病预后的影响最大，因此安全性和有效性是至关重要的。对于2019冠状病毒疾病，二甲双胍是最常用的一线药物，但其对COVID-19和T2D患者预后的影响有待进一步阐明。2019冠状病毒疾病2019冠状病毒疾病的1213例住院患者的回顾性研究表明二甲双胍的使用与酸中毒发病率显著相关，尤其是在严重COVID-19的病例中，而不是28天COVID-19相关死亡率。此外，二甲双胍的使用与心力衰竭和炎症的减少显著相关。我们的2019冠状病毒疾病2019冠状病毒疾病的治疗结果表明，在严重COVID-19的个体中，应仔细监测酸中毒和肾功能。

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  • 来源
    《Cell metabolism》 |2020年第4期|共14页
  • 作者

    Cheng Xu; Liu Ye-O; Li Haomiao; Zhang Xin; Lei Fang; Qin Juan-Juan; Chen Ze; Deng Ke-Qiong; Lin Lijin; Chen Ming-Ming; Song Xiaohui; Xia Meng; Huang Xuewei; Liu Weifang; Cai Jingjing; Zhang Xiao-Jing; Zhou Feng; Zhang Peng; Wang Yibin; Ma Xinliang; Xu Qingbo; Yang Juan; Ye Ping; Mao Weiming; Huang Xiaodong; Xia Jiahong; Zhang Bing-Hong; Guo Jiao; Zhu Lihua; Lu Zhibing; Yuan Yufeng; Wei Xiang; She Zhi-Gang; Ji Yan-Xiao; Li Hongliang;

  • 作者单位

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

    Cent South Univ Xiangya Hosp 3 Dept Cardiol Changsha 410000 Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Univ Calif Los Angeles David Geffen Sch Med Dept Anesthesiol Cardiovasc Res Labs Los Angeles;

    Thomas Jefferson Univ Dept Emergency Med Philadelphia PA 19004 USA;

    Queen Mary Univ London Ctr Clin Pharmacol William Harvey Res Inst London England;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Huazhong Univ Sci &

    Technol Cent Hosp Wuhan Tongji Med Coll Dept Cardiol Wuhan Peoples R China;

    Huanggang Cent Hosp Dept Gen Surg Huanggang Peoples R China;

    Wuhan Univ Dept Gastroenterol Wuhan Hosp 3 Wuhan Peoples R China;

    Huazhong Univ Sci &

    Technol Union Hosp Tongji Med Coll Dept Cardiovasc Surg Wuhan Peoples R;

    Wuhan Univ Dept Neonatol Renmin Hosp Wuhan Peoples R China;

    Guangdong Pharmaceut Univ Guangdong Metab Dis Res Ctr Integrated Chinese &

    Guangdong TCM Key Lab;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

    Wuhan Univ Dept Hepatobiliary &

    Pancreat Surg Zhongnan Hosp Wuhan Peoples R China;

    Huazhong Univ Sci &

    Technol Tongji Hosp Tongji Med Coll Div Cardiothorac &

    Vasc Surg Wuhan;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Inst Model Anim Wuhan Peoples R China;

    Wuhan Univ Zhongnan Hosp Sch Basic Med Sci Dept Cardiol Wuhan Peoples R China;

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  • 中图分类 内分泌腺疾病及代谢病;
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