• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell biology international. >Heparan sulfate maintains adult midgut homeostasis in Drosophila Drosophila
【24h】

Heparan sulfate maintains adult midgut homeostasis in Drosophila Drosophila

机译：硫酸乙酰肝素在果蝇果蝇中保持成人胚胎稳态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Tissue homeostasis is controlled by the differentiated progeny of residential progenitors (stem cells). Adult stem cells constantly adjust their proliferation/differentiation rates to respond to tissue damage and stresses. However, how differentiated cells maintain tissue homeostasis remains unclear. Here, we find that heparan sulfate (HS), a class of glycosaminoglycan (GAG) chains, protects differentiated cells from loss to maintain intestinal homeostasis. HS depletion in enterocytes (ECs) leads to intestinal homeostasis disruption, with accumulation of intestinal stem cell (ISC)‐like cells and mis‐differentiated progeny. HS‐deficient ECs are prone to cell death/stress and induced cytokine and epidermal growth factor (EGF) expression, which, in turn, promote ISC proliferation and differentiation. Interestingly, HS depletion in ECs results in the inactivation of decapentaplegic (Dpp) signaling. Moreover, ectopic Dpp signaling completely rescued the defects caused by HS depletion. Together, our data demonstrate that HS is required for Dpp signal activation in ECs, thereby protecting ECs from ablation to maintain midgut homeostasis. Our data shed light into the regulatory mechanisms of how differentiated cells contribute to tissue homeostasis maintenance.
机译：摘要组织内环境稳定由居住的祖细胞（干细胞）的分化后代控制。成人干细胞不断调整其增殖/分化率，以应对组织损伤和压力。然而，分化细胞是如何维持组织内环境稳定的尚不清楚。在这里，我们发现硫酸乙酰肝素（HS）是一类糖胺聚糖（GAG）链，可以保护分化细胞免受丢失，从而维持肠道内环境平衡。肠细胞（ECs）中的HS缺失会导致肠道内稳态破坏，导致肠道干细胞（ISC）样细胞和分化不良的后代聚集。缺乏HS的内皮细胞容易发生细胞死亡/应激，并诱导细胞因子和表皮生长因子（EGF）表达，进而促进ISC增殖和分化。有趣的是，内皮细胞中HS的缺失导致十五瘫（Dpp）信号的失活。此外，异位Dpp信号完全挽救了HS耗竭引起的缺陷。总之，我们的数据表明HS是ECs中Dpp信号激活所必需的，从而保护ECs免受消融，以维持中肠内稳态。我们的数据揭示了分化细胞如何促进组织内稳态维持的调节机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号