• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Characterization of CD4(+) T cell-mediated cytotoxicity in patients with multiple myeloma
【24h】

Characterization of CD4(+) T cell-mediated cytotoxicity in patients with multiple myeloma

机译：多发性骨髓瘤患者CD4（+）T细胞介导细胞毒性的表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Multiple myeloma (MM) is an incurable cancer characterized by the development of malignant plasma cells. The CD8 T cell-mediated cytotoxicity is considered a major player in antitumor immunity, but in MM patients, the CD8 T cells displayed senescence markers and were functionally impaired. To investigate whether cytotoxic CD4 T cells could act as a treatment alternative in MM, we examined the frequency and function of naturally occurring cytotoxic CD4 T cells in MM patients. The cytotoxic CD4 T cells were identified as granzyme-A, granzyme B-, and perforin-expressing CD4 T cells, and their frequencies were significantly upregulated in MM patients when compared with healthy controls. The frequencies of cytotoxic CD4 T cells in MM patients were not associated with the frequencies of cytotoxic CD8 T cells, but were negatively associated with disease severity. Interestingly, the expression levels of inhibitory molecules, including PD-1 and CTLA-4, were significantly lower in cytotoxic CD4 T cells than in cytotoxic CD8 T cells. When co-incubated with autologous CD38(+) CD138(+) plasma cells, CD4 T cells were capable of eliminating plasma cells with varying degrees of efficacy. In MM patients, the frequency of circulating plasma cells was negatively correlated with the frequency of cytotoxic CD4 T cells. Therefore, CD4 T cell-mediated cytotoxicity existed naturally in MM patients and could potentially act as an option in antitumor therapies.
机译：多发性骨髓瘤（MM）是一种以恶性浆细胞为特征的不可治愈的癌症。CD8 T细胞介导的细胞毒性被认为是抗肿瘤免疫的主要参与者，但在MM患者中，CD8 T细胞显示衰老标志物，功能受损。为了研究细胞毒性CD4 T细胞是否可以作为MM的替代治疗方案，我们检测了MM患者中自然产生的细胞毒性CD4 T细胞的频率和功能。细胞毒性CD4 T细胞被鉴定为颗粒酶A、颗粒酶B-和表达穿孔素的CD4 T细胞，与健康对照组相比，MM患者的频率显著上调。MM患者的细胞毒性CD4 T细胞频率与细胞毒性CD8 T细胞频率无关，但与疾病严重程度呈负相关。有趣的是，包括PD-1和CTLA-4在内的抑制性分子在细胞毒性CD4 T细胞中的表达水平显著低于细胞毒性CD8 T细胞。当与自体CD38（+）CD138（+）浆细胞共同培养时，CD4 T细胞能够以不同程度的效力清除浆细胞。在MM患者中，循环浆细胞的频率与细胞毒性CD4 T细胞的频率呈负相关。因此，CD4 T细胞介导的细胞毒性在MM患者中自然存在，并可能作为抗肿瘤治疗的一种选择。

著录项

  • 来源
    《Cellular immunology》 |2018年第2018期|共6页
  • 作者

    Zhang Xiaole; Gao Lei; Meng Kai; Han Chunting; Li Qiang; Feng Zhenjun; Chen Lei;

  • 作者单位

    Liaocheng Peoples Hosp Dept Hematol 67 Dongchang West Rd Liaocheng 252000 Shandong Peoples R;

    Liaocheng Peoples Hosp Dept Hematol 67 Dongchang West Rd Liaocheng 252000 Shandong Peoples R;

    Liaocheng Blood Ctr Liaocheng Shandong Peoples R China;

    Liaocheng Vocat &

    Tech Coll Liaocheng Shandong Peoples R China;

    Liaocheng Peoples Hosp Dept Hematol 67 Dongchang West Rd Liaocheng 252000 Shandong Peoples R;

    Liaocheng Peoples Hosp Dept Hematol 67 Dongchang West Rd Liaocheng 252000 Shandong Peoples R;

    Liaocheng Peoples Hosp Dept Hematol 67 Dongchang West Rd Liaocheng 252000 Shandong Peoples R;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Cytotoxic CD4 T cell; Multiple myeloma; T cell immunity;

    机译：细胞毒性CD4 T细胞;多发性骨髓瘤;T细胞免疫力;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号