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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Dietary Supplementation of Octacosanol Improves Exercise-Induced Fatigue and Its Molecular Mechanism
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Dietary Supplementation of Octacosanol Improves Exercise-Induced Fatigue and Its Molecular Mechanism

机译：八氰醇的膳食补充改善了运动诱导的疲劳及其分子机制

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摘要

Several publications report that octacosanol (OCT) has different biological functions. This study was designed to evaluate the antifatigue effect and molecular mechanism of octacosanol (200 mg/(kg day)) in forced exercise-induced fatigue models of trained male C57BL/6 mice. Results showed that octacosanol ameliorated the mice's autonomic activities, forelimb grip strength, and swimming endurance, and the levels of liver glycogen (LG), muscle glycogen (MG), blood lactic acid (BLA), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were also regulated. Gene analysis results showed that treatment with OCT upregulated 29 genes, while 38 genes were downregulated in gastrocnemius tissue. Gene ontology (GO) analyses indicated that these genes enriched functions in relation to myofibril, contractile fiber, and calcium-dependent adenosinetriphosphatase (ATPase) activity. Octacosanol supplementation significantly adjusted the messenger RNA (mRNA) and protein expression levels related to fatigue performance. Octacosanol has an observably mitigating effect in exercise-induced fatigue models, and its molecular mechanism may be related to the regulation of tripartite motif-containing 63 (Trim63), periaxin (Prx), calcium voltage-gated channel subunit a1 H (Cacna1h), and myosin-binding protein C (Mybpc3) expression.
机译：一些出版物报道二十八烷醇（OCT）具有不同的生物学功能。本研究旨在评估二十八烷醇（200mg/（kg-d））在训练雄性C57BL/6小鼠的强迫运动诱导疲劳模型中的抗疲劳作用和分子机制。结果表明，二十八烷醇改善了小鼠的自主活动、前肢握力和游泳耐力，并调节了肝糖原（LG）、肌糖原（MG）、血乳酸（BLA）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的水平。基因分析结果显示，OCT可上调29个基因，而在腓肠肌组织中有38个基因下调。基因本体（GO）分析表明，这些基因丰富了与肌原纤维、收缩纤维和钙依赖性腺苷三磷酸酶（ATP酶）活性相关的功能。补充二十八烷醇可显著调节与疲劳表现相关的信使RNA（mRNA）和蛋白质表达水平。二十八烷醇在运动性疲劳模型中具有明显的缓解作用，其分子机制可能与调节含有63（Trim63）、periaxin（Prx）、钙电压门控通道亚基a1 H（Cacna1h）和肌球蛋白结合蛋白C（Mybpc3）的三元基序有关。

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  • 来源
  • 作者

    Zhou Yaping; Cao Fuliang; Wu Qiang; Luo Yi; Guo Tianyi; Han Shuai; Huang Mengzhen; Hu Zuomin; Bai Jie; Luo Feijun; Lin Qinlu;

  • 作者单位

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Nanjing Forestry Univ Coll Forestry Coinnovat Ctr Sustainable Forestry Southern China Nanjing 210037 Jiangsu Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Med Coll Xiangya Dept Clin Med Changsha 410008 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

    Cent South Univ Forestry &

    Technol Natl Engn Lab Deep Proc Rice &

    Byprod Coll Food S Hunan Key Lab Grain Oil Deep Proc &

    Qual Control Hunan Key Lab Processed Food Special Med Purpose Changsha 410004 Hunan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    antifatigue; octacosanol; energy and endurance performance; biochemical parameters; microarray; molecular mechanism;

    机译：抗皱;辛辣糖;能量和耐力性能;生物化学参数;微阵列;分子机制;

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