Acetylxylan-pheophorbide-a nanoparticles designed for tumor-targeted photodynamic therapy

Bouramtane Soukaina; Bretin Ludovic; Pinon Aline; Leger David; Liagre Bertrand; Perez Denilson Da Silva; Launay Yann; Bregier Frederique; Sol Vincent; Chaleix Vincent

首页> 外文期刊>Journal of Applied Polymer Science >Acetylxylan-pheophorbide-a nanoparticles designed for tumor-targeted photodynamic therapy

【24h】

Acetylxylan-pheophorbide-a nanoparticles designed for tumor-targeted photodynamic therapy

机译：乙酰丁基 - 噬冰蛋白 - 一种专为肿瘤靶向光动力治疗而设计的纳米粒子

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The poor solubility of most photosensitizers (PS) hampers their practical use as clinical agents. Conjugation of PS with water-soluble nanoparticles has been often used to bypass this hurdle. We describe in this study the extraction of glucuronoacetylxylan from chestnut sawdust, the hemisynthesis of pheophorbide-a (Pha) and its covalent attachment to xylan. The resulting conjugates (xyl-Pha) spontaneously form water-soluble spherical nanoparticles (xyl-Pha NPs) ranging between 100 and 250 nm in diameter. Assayed against the HT-29 colorectal cancer cell line, xyl-Pha NPs exhibited a dose-dependent phototoxicity only when irradiated with red light.

机译：大多数光敏剂（PS）溶解性差，阻碍了其作为临床药物的实际应用。PS与水溶性纳米颗粒的结合经常被用来绕过这一障碍。本研究描述了从板栗锯末中提取葡萄糖醛酸乙酰木聚糖，半合成脱镁叶绿酸-a（Pha）及其与木聚糖的共价连接。由此产生的共轭物（xyl-Pha）自发形成直径在100到250纳米之间的水溶性球形纳米颗粒（xyl-Pha NP）。通过对HT-29结直肠癌细胞系的检测，xyl-Pha NP仅在红光照射下表现出剂量依赖性光毒性。

著录项

来源
《Journal of Applied Polymer Science》 |2021年第32期|共9页
作者
Bouramtane Soukaina; Bretin Ludovic; Pinon Aline; Leger David; Liagre Bertrand; Perez Denilson Da Silva; Launay Yann; Bregier Frederique; Sol Vincent; Chaleix Vincent;
展开▼
作者单位

Univ Limoges Fac Sci &

Tech EA 7500 Lab PEIRENE 123 Ave Albert Thomas F-87060 Limoges France;

Univ Limoges Fac Pharm EA 7500 Lab PEIRENE Limoges France;

Univ Limoges Fac Pharm EA 7500 Lab PEIRENE Limoges France;

Univ Limoges Fac Pharm EA 7500 Lab PEIRENE Limoges France;

Univ Limoges Fac Pharm EA 7500 Lab PEIRENE Limoges France;

FCBA Inst Technol InTechFibres Div Grenoble France;

Univ Limoges Ctr Europeen Ceram Limoges France;

Univ Limoges Fac Sci &

Tech EA 7500 Lab PEIRENE 123 Ave Albert Thomas F-87060 Limoges France;

Univ Limoges Fac Sci &

Tech EA 7500 Lab PEIRENE 123 Ave Albert Thomas F-87060 Limoges France;

Univ Limoges Fac Sci &

Tech EA 7500 Lab PEIRENE 123 Ave Albert Thomas F-87060 Limoges France;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类高分子化合物工业（高聚物工业）;
关键词
xylan; polysaccharides; nanoparticles; photodynamic therap; selfamp; 8208; assembly; pheophorbideamp; 8208; a; colorectal cancer;

机译：木聚糖;多糖;纳米粒子;光动力学疗法;自我＆amp;8208;组装;野生植物;8208;一个;结直肠癌;

相似文献

外文文献
中文文献
专利

1. Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment [J] . Huanyu Yang, Renfa Liu, Yunxue Xu, 纳微快报：英文版 . 2021,第002期
2. PCN-Fe(Ⅲ)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia [J] . Tao Zhang, Zhenqi Jiang, Libin Chen, 纳米研究：英文版 . 2020,第001期
3. PCN-Fe(Ⅲ)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia [J] . Tao Zhang, Pintong Huang, Zhenqi Jiang, 纳米研究（英文版） . 2020,第001期
4. GSH-responsive SN38 dimer-loaded shape-transformable nanoparticles with iRGD for enhancing chemo-photodynamic therapy [J] . Congcong Lin, Fan Tong, Rui Liu, 药学学报（英文版） . 2020,第012期
5. Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging [J] . Chen Guojun, Jaskula-Sztul Renata, Esquibel Corinne R., Advanced Functional Materials . 2017,第8期

机译：基于神经内分泌肿瘤靶向的上转换纳米粒子的胶束，用于同时进行近红外控制的联合化学疗法和光动力疗法以及荧光成像
6. Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy [J] . Ming Qin, Hoe Jin Hah, Gwangseong Kim, Photochemical & Photobiological Sciences . 2011,第5期

机译：亚甲蓝共价负载聚丙烯酰胺纳米粒子用于增强肿瘤靶向的光动力治疗
7. Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy [J] . Ming Qin, Hoe Jin Hah, Gwangseong Kim Photochemical & photobiological sciences: the official journal of the European Photochemistry Association and the European Society for Photobiology . 2011,第5期

机译：亚甲蓝共价负载聚丙烯酰胺纳米颗粒用于增强肿瘤靶向的光动力治疗
8. Folate receptor-mediated tumor-targeted upconversion nanocomplex for photodynamic therapy triggered by near-infrared light [C] . Sisi Cui, Haiyan Chen, Zhiyu Qian, Biophotonics and immune responses VIII . 2013

机译：叶酸受体介导的肿瘤靶向的上转换纳米复合物，用于近红外光触发的光动力治疗
9. The design and synthesis of chalcogenoxanthylium dyes for use as photosensitizers in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT). [D] . Donnelly, David Joseph. 2006

机译：设计和合成硫属黄原蒽染料，用作光动力疗法（PDT）和光动力抗菌化学疗法（PACT）中的光敏剂。
10. NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging [O] . Linlin Zhao, Jongseon Choi, Yan Lu, 2020

机译：基于六边相上变频纳米粒子的NIR光学灭菌系统用于肿瘤靶向光动力治疗和荧光成像
11. NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging [O] . Linlin Zhao, Jongseon Choi, Yan Lu, 2020

机译：基于六边相上变频纳米粒子的NIR光学灭菌系统用于肿瘤靶向光动力治疗和荧光成像
12. Radiopaque, Tumor-Targeted Nanoparticles for Improved Mammographic Detection of Breast Cancer [R] . Adams, G. P. 2007

机译：不透射线，肿瘤靶向纳米粒子用于改善乳腺癌的乳腺摄影检测

Acetylxylan-pheophorbide-a nanoparticles designed for tumor-targeted photodynamic therapy

摘要

著录项

相似文献

相关主题

期刊订阅