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首页> 外文期刊>Journal of Applied Polymer Science >Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine
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Green synthesis and characterization of poly(glycerol-azelaic acid) and its nanocomposites for applications in regenerative medicine

机译：聚（甘油 - 壬二酸）的绿色合成与表征及其纳米复合材料在再生医学中的应用

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摘要

A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by H-1-NMR, C-13-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.
机译：采用原位聚合法制备了一系列以甘油和壬二酸为单体，加入羟基磷灰石（HA）纳米颗粒的新型生物聚酯纳米复合材料。通过H-1-NMR、C-13-NMR和傅里叶变换红外光谱（FTIR）研究了样品的化学结构。能量色散X射线图谱分析表明，纳米颗粒在聚（甘油壬二酸）（PGAZ）基质中分散良好。研究了样品在不同频率下的粘弹性，其中含有1.0 wt%HA纳米颗粒（PGAZH1.0）的PGAZ样品表现出最优异的性能。此外，还对样品玻璃化转变温度的变化进行了综合讨论。热重分析显示，纳米复合材料的降解模式通常与原始样品不同。动态接触角表明，HA纳米颗粒的存在对亲水性有显著影响。测量pH=7和pH=11时的水解降解值，并确定含有1.5 wt%HA（PGAZH1.5）的PGAZ样品的降解率高于其他样品。此外，体外研究表明细胞附着在PGAZH1上。0和PAZH1。5个表面合格。

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