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Spectrophotometric methods for the estimation of cinitapride and pantoprazole in bulk and oral dosage form

机译：分光光度法估算散装和口服剂型中的西尼他必利和pan托拉唑

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摘要

Different UV spectrophotometric methods have been developed for the estimation of cinitapride (CNP) and pantoprazole (PNP) in both bulk and capsule dosage form. Both the drugs were well soluble in methanol. CNP and PNP showed maximum absorption at 262nm and 290nm respectively using methanol as solvent. CNP obeyed Beer's law, showing linearity in the range of 4-20and PNP at 5-30 μg/ml with correlation coefficient of 1 for both. Method A is based on standard absorbance, method B involves determination of the Area under curve (AUC) and method C makes use of second derivative of the Zero order spectrum. The developed methods were analyzed for specificity, limit of detection (LOD), limit of quantification (LOQ), linearity of response, precision and accuracy. Thus the proposed method could be adopted for routine analysis of the formulation.
机译：已经开发了不同的紫外分光光度法来估算散装和胶囊剂型中的西尼他必利（CNP）和pan托拉唑（PNP）。两种药物均易溶于甲醇。以甲醇为溶剂，CNP和PNP分别在262nm和290nm处显示出最大吸收。 CNP遵循比尔定律，在4-20和PNP范围为5-30μg/ ml时呈线性关系，两者的相关系数均为1。方法A基于标准吸光度，方法B涉及确定曲线下面积（AUC），方法C使用零阶光谱的二阶导数。分析了开发的方法的特异性，检测限（LOD），定量限（LOQ），响应线性，精确度和准确性。因此，所提出的方法可以用于制剂的常规分析。

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