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首页> 外文期刊>Cytokine >Leishmania donovani mediated higher expression of CCL4 induces differential accumulation of CD4 + CD56 + NKT and CD8 + CD56 + NKT cells at infection site
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Leishmania donovani mediated higher expression of CCL4 induces differential accumulation of CD4 + CD56 + NKT and CD8 + CD56 + NKT cells at infection site

机译：Leishmania Donovani介导的CCl4诱导CCL4的更高表达诱导CD4 + CD56 + NKT和CD8 + CD56 + NKT细胞的差异积聚在感染部位

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摘要

Sterile cure from visceralizedLeishmania donovani(L. donovani) needs Th1 cell support along with the assistance from innate immune cells, NK cells and NKT cells. NKT cells play as a connecting link between innate and adaptive immune cell and support T helper cell function. Earlier, a categorical function of CD56 positive CD4+or CD8+NKT cells was reported in visceral leishmaniasis (VL). It was observed inin vitrothat CD4+CD56+NKT cells, but not CD8+CD56+NKT cells, were accumulated at theL. donovaniinfection site. Therefore,in vitroexperiments have been carried out to decipher the mechanism behind preferential accumulation of CD4+CD56+NKT cells at infection site. In this study, 1.89 fold higher expression of CCL4/MIP-1β was noticed in infected macrophages. The higher expression of CCL4 was correlated with preferential accumulation of CCR5+CD4+CD56+NKT cells and apoptosis of CD8+CD56+NKT cells atin vitroinfection site. The CD4+CD56+NKT cells were also observed expressing TGF-β dominantly. Interaction of CCL4 chemotaxis was interrupted by blocking, which led to drift back the TGF-β producing CD4+CD56+NKT cells and promoted CD8+CD56+NKT cells recruitment inin vitroinfection site. CCR5 blockade also reduced CD25 and FoxP3 positive CD4+CD56+NKT cells inin vitroinfection site. Therefore, it was concluded thatLeishmaniapromotes strategic expression of CCL4, which alternately attracts CCR5+cells, mostly expressing regulatory cytokines, at infection site. This reduces the CD8+CD56+NKT cells at infection site through Smad4 mediated TGF-β expression and activation of caspases. Data indicates thatL. donovaniinduces higher expression of CCL4 in host cell to attract CCR5+cells under its strategic plan to downregulate host immune response.
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  • 来源
    《Cytokine》 |2018年第2018期|共10页
  • 作者

    Sarita Kumari; Pushkar Shivam; Shashank Kumar; Fauzia Jamal; Manish Kumar Singh; Sanjiva Bimal; Shyam Narayan; Krishna Pandey; Vidya Nand Ravi Das; Pradeep Das; Shubhankar K. Singh;

  • 作者单位

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

    Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research);

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Natural killer T cells; Visceral leishmaniasis; Leishmania donovani; Chemokine;

    机译：天然杀手T细胞;内脏Leishmaniaisis;Leishmania Donovani;趋化因子;

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