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The asthma‐rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

机译：哮喘 - 鼻炎多药物与青少年和成人的IgE聚敏化有关

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摘要

Abstract Background Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. Methods IgE reactivity to 64 micro‐arrayed aeroallergen molecules was determined with the Me DALL ‐chip in samples from the French EGEA study (n = 840, age = 40.7 ± 17.1) and the Swedish population‐based birth cohort BAMSE (n = 786, age = 16 ± 0.26). The age‐ and sex‐adjusted associations between the number of IgE‐reactive allergen molecules (≥0.3 ISU ) and the asthma‐rhinitis phenotypes were assessed using a negative binomial model. Results Groups representing 4 phenotypes were identified: no asthma‐no rhinitis (A?R?; 30% in EGEA and 54% in BAMSE ), asthma alone (A+R?; 11% and 8%), rhinitis alone (A?R+; 15% and 24%) and asthma‐rhinitis (A+R+; 44% and 14%). The numbers of IgE‐reactive aeroallergen molecules significantly differed between phenotypes (median in A?R?, A+R?, A?R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE ). As compared to A?R? subjects, the adjusted ratio of the mean number of IgE‐reactive molecules was higher in A+R+ than in A+R? or A?R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE ). Conclusion The A+R+ phenotype combined the sensitization pattern of both the A?R+ and A+R? phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.
机译：None

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  • 来源
    《Allergy》 |2018年第7期|共12页
  • 作者

    Siroux V.; Ballardini N.; Soler M.; Lupinek C.; Boudier A.; Pin I.; Just J.; Nadif R.; Anto J. M.; Melen E.; Valenta R.; Wickman M.; Bousquet J.;

  • 作者单位

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Division of ImmunopathologyMedical University of ViennaVienna Austria;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Inserm CNRS IABUniversity Grenoble AlpesGrenoble France;

    Allergology DepartmentChildren Hospital Armand TrousseauParis France;

    Inserm U1168VIMA: Aging and Chronic Diseases Epidemiological and Public Health;

    ISGLoBALCentre for Research in Environmental Epidemiology (CREAL)Barcelona Spain;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Division of ImmunopathologyMedical University of ViennaVienna Austria;

    Institute of Environmental MedicineKarolinska InstitutetStockholm Sweden;

    Inserm U1168VIMA: Aging and Chronic Diseases Epidemiological and Public Health;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergens; epidemiology; multimorbidity; polysensitization; specific IgE;

    机译：过敏原;流行病学;多元化;聚敏化;特定的IgE;

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