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首页> 外文期刊>Analytica chimica acta >Optimization of the buffer system of micellar electrokinetic capillary chromatography for the separation of the active components in Chinese medicine 'SHUANGDAN' granule by genetic algorithm
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Optimization of the buffer system of micellar electrokinetic capillary chromatography for the separation of the active components in Chinese medicine 'SHUANGDAN' granule by genetic algorithm

机译：胶束电动毛细管色谱缓冲体系遗传算法分离中药双丹活性成分的优化。

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摘要

Genetic algorithm (GA) was employed to optimize the buffer system of micellar electrokinetic capillary chromatography (MEKC) for separating the active components contained in Chinese medicines. 'SHUANGDAN' granule, an important botanical drug in the treatment of cardiovascular diseases in China, was studied as a typical example. The optimized buffer system (25 mM borate, 29 mM phosphate and 50 mM SDS) provides the best separation with regard to resolution and analysis time. In order to validate the performance of the optimized result, different analytical parameters (e.g., precision, linearity range and recovery) of MEKC method were calculated based on the optimized separation to simultaneously determine protocatechuic aldehyde, paeonol, danshensu and salvianolic acid B contained in 'SHUANGDAN' granule. It was shown that GA is an effective tool for optimizing the separation of a series of active components contained in Chinese medicines by capillary electrophoresis. (c) 2006 Elsevier B.V. All rights reserved.
机译：采用遗传算法（GA）优化胶束电动毛细管色谱（MEKC）的缓冲体系，以分离中药中的有效成分。典型的例子是研究在中国治疗心血管疾病的重要植物药“双DAN”颗粒。优化的缓冲液系统（25 mM硼酸盐，29 mM磷酸盐和50 mM SDS）在分离度和分析时间方面提供了最佳分离效果。为了验证优化结果的性能，在优化分离的基础上计算了MEKC方法的不同分析参数（例如，精密度，线性范围和回收率），从而同时测定了'K'中所含的原儿茶醛，丹皮酚，丹参素和丹酚酸B。双丹颗粒。结果表明，GA是通过毛细管电泳优化分离中药中一系列活性成分的有效工具。 （c）2006 Elsevier B.V.保留所有权利。

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