• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of microbiology >Artesunate inhibits Staphylococcus aureus biofilm formation by reducing alpha-toxin synthesis
【24h】

Artesunate inhibits Staphylococcus aureus biofilm formation by reducing alpha-toxin synthesis

机译：通过减少α-毒素合成来抑制金黄色葡萄球菌的葡萄球菌形成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Staphylococcus aureus is one of the most common pathogens in bacterial biofilm infections. Antibiotic treatment for infection caused by S. aureus biofilms is challenging, and few effective strategies have been developed to combat these infections. The aim of this study was to investigate the effect and possible mechanisms of artesunate on the biofilm formation of S. aureus. Bacterial growth curves were determined by a microtiter plate. Biofilm formation was determined by the crystal violet staining method and confocal laser scanning microscopy. Bacterial adhesion was assayed by the colony-counting method. The expression of virulence and adhesion genes was determined by real-time PCR. The hemolytic activity and expression of.-hemolysin were analyzed using rabbit erythrocytes and Western blotting. The results showed that artesunate could significantly inhibit the biofilm formation of S. aureus in a dose-dependent manner. Artesunate could also inhibit bacterial adhesion and the expression of hla, RNAIII and agrA as well as.-hemolysin production. The effect of artesunate on adhesion genes (clfA, clfB, fnbA, fnbB) had strain specificity, but it did not affect the expression of ica genes. The results indicated that artesunate might inhibit.-hemolysin synthesis by the agr system, which inhibits biofilm formation.
机译：None

著录项

  • 来源
    《Archives of microbiology》 |2021年第2期|共11页
  • 作者

    Qian Yan; Xia Li; Wei Lai; Li Di; Jiang Weiwei;

  • 作者单位

    Chongqing Med Univ Affiliated Hosp 2 Dept Pharm 76 Linjiang Rd Chongqing 400010 Peoples R China;

    Chongqing Tradit Chinese Med Hosp Dept Liver Dis Chongqing 400021 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 2 Dept Pharm 76 Linjiang Rd Chongqing 400010 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 2 Dept Pharm 76 Linjiang Rd Chongqing 400010 Peoples R China;

    Chongqing Med Univ Affiliated Hosp 2 Dept Pharm 76 Linjiang Rd Chongqing 400010 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

    Artesunate; Staphylococcus aureus; Biofilm; alpha-hemolysin; Adhesion;

    机译：artesunate;金黄色葡萄球菌;生物膜;α-溶血素;粘附;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号