Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, gamma-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy

Gonen Ofer M.; Moffat Bradford A.; Desmond Patricia M.; Lui Elaine; Kwan Patrick; OBrien Terence J.

首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, gamma-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy

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Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, gamma-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy

机译：糖酰胺，γ-氨基丁酸的七级定量磁共振光谱，癫痫患者的后刺刺肌粘土酸和谷胱甘肽

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Objective The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and gamma-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the most important free radical scavenging compound in the brain. Quantification of these molecules by magnetic resonance spectroscopy (MRS) up to 4 T is limited by overlapping resonances from other molecules. In this study, we used ultra-high-field (7 T) MRS to quantify their concentrations in patients with different epilepsy syndromes.

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来源
《Epilepsia: Journal of the International League against Epilepsy》 |2020年第12期|共10页
作者
Gonen Ofer M.; Moffat Bradford A.; Desmond Patricia M.; Lui Elaine; Kwan Patrick; OBrien Terence J.;
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作者单位

Royal Melbourne Hosp Dept Neurol 300 Grattan St Parkville Vic 3050 Australia;

Univ Melbourne Dept Med &

Radiol Parkville Vic Australia;

Univ Melbourne Dept Med &

Radiol Parkville Vic Australia;

Univ Melbourne Dept Med &

Radiol Parkville Vic Australia;

Royal Melbourne Hosp Dept Neurol 300 Grattan St Parkville Vic 3050 Australia;

Royal Melbourne Hosp Dept Neurol 300 Grattan St Parkville Vic 3050 Australia;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
default mode network; epilepsy; glutathione; MRS; posterior cingulate cortex; precuneus;

机译：默认模式网络;癫痫;谷胱甘肽;MRS;后筒皮层;PRIENEUS;

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Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, gamma-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy

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