Coeliac disease: further evidence that biopsy is not always necessary for diagnosis

Holmes Geoffrey K. T.; Forsyth Julia M.; Knowles Sarah; Seddon Helen; Hill Peter G.; Austin Andrew S.

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Coeliac disease: further evidence that biopsy is not always necessary for diagnosis

机译：乳糜泻：进一步证据表明活检并不总是需要诊断

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Objectives Growing evidence supports the view that the diagnosis of coeliac disease (CD) can be made by serological tests alone, although this approach is still not widely accepted. We previously showed in retrospective and prospective studies that in adults an IgA-tissue transglutaminase antibody cut-off can be defined above which the positive predictive value for CD is 100%. Following a change in the analytical method for measuring the antibody, our objectives were to re-examine this finding in a larger series of adults to ascertain whether a diagnosis of CD can be reliably made in a proportion of patients without the need for small bowel biopsy and to re-evaluate the diagnostic guidelines used in our centre.

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来源
《European journal of gastroenterology and hepatology》 |2017年第6期|共6页
作者
Holmes Geoffrey K. T.; Forsyth Julia M.; Knowles Sarah; Seddon Helen; Hill Peter G.; Austin Andrew S.;
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作者单位

Royal Derby Hosp Derby DE22 3NE England;

Royal Derby Hosp Dept Pathol Derby England;

Royal Derby Hosp Dept Pathol Derby England;

Royal Derby Hosp Dept Pathol Derby England;

Royal Derby Hosp Derby DE22 3NE England;

Royal Derby Hosp Derby Digest Dis Ctr Derby England;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
coeliac disease; diagnostic tests; immunology; small intestine;

机译：乳糜泻;诊断测试;免疫学;小肠;

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3. Coeliac disease: further evidence that biopsy is not always necessary for diagnosis [J] . Holmes Geoffrey K. T., Forsyth Julia M., Knowles Sarah, European journal of gastroenterology and hepatology . 2017,第6期

机译：乳糜泻：进一步证据表明活检并不总是需要诊断
4. Coeliac disease: further evidence that biopsy is not always necessary for diagnosis [J] . Holmes Geoffrey K. T., Hill Peter G. European journal of gastroenterology and hepatology . 2017,第10期

机译：乳糜泻：进一步证据表明活检并不总是需要诊断
5. Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts [J] . Hugo A Penny, Suneil A Raju, Michelle S Lau, Gut: Journal of the British Society of Gastroenterology . 2021,第5期

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Coeliac disease: further evidence that biopsy is not always necessary for diagnosis

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