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首页> 外文期刊>Behavioural Brain Research: An International Journal >Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice
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Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice

机译：牙齿脱落导致APP转基因小鼠记忆力减退和神经细胞丢失

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摘要

Tooth loss is a known risk factor of Alzheimer's disease (AD). However, the association of tooth loss with the molecular pathogenesis of AD is still unknown. The hypothesis that the molecular pathogenesis of AD is enhanced by molar tooth loss was tested. Seventeen female transgenic mice (J20) were divided into the experimental (EX, n= 10) and control (C, n= 7) groups. In the EX group, maxillary bilateral molar teeth were extracted at the age of 6 months. In the C group, however, these teeth remained intact. Passive avoidance test was performed to evaluate learning and memory abilities right after tooth extraction (6 months old) and 4 months later (10 months old). After the test at 10 months, amyloid beta (Aβ) deposition and changes of neuronal cell number and area in the hippocampus were investigated using half of the brains. The other half was homogenized and used to determine Aβ40 and Aβ42 levels by ELISA. At the 10 months of age, learning and memory abilities were significantly impaired in the EX group compared to the C group (P< 0.05). The neuronal cell number in the CA1 and CA3 regions was significantly lower in the EX group than in the C group (P< 0.05). Total Aβ, Aβ40, and Aβ42 levels showed no significant intergroup difference. Molar tooth loss may cause neuronal cell loss in the hippocampus, leading to memory impairment; this process may be independent of the amyloid cascade.
机译：牙齿脱落是阿尔茨海默氏病（AD）的已知危险因素。然而，牙齿脱落与AD的分子发病机理的关系仍然未知。测试了摩尔磨牙缺失会增强AD分子发病机理的假说。将十七只雌性转基因小鼠（J20）分为实验组（EX，n = 10）和对照组（C，n = 7）。在EX组中，上颌双侧磨牙在6个月大时拔出。然而，在C组中，这些牙齿保持完整。在拔牙后（6个月大）和4个月后（10个月大）进行被动回避测试以评估学习和记忆能力。在10个月的测试后，使用一半的大脑研究了淀粉样β（Aβ）沉积以及海马神经元细胞数量和面积的变化。将另一半匀浆并通过ELISA用于测定Aβ40和Aβ42水平。与C组相比，EX组在10个月大时，学习和记忆能力显着受损（P <0.05）。 EX组的CA1和CA3区域的神经元细胞数量显着低于C组（P <0.05）。总Aβ，Aβ40和Aβ42水平未显示明显的组间差异。磨牙缺失可能会导致海马神经细胞丢失，从而导致记忆力减退;这个过程可能独立于淀粉样蛋白级联反应。

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