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首页> 外文期刊>Annals of hematology >Central venous catheter-associated bloodstream infection and colonisation of insertion site and catheter tip. What are the rates and risk factors in haematology patients?
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Central venous catheter-associated bloodstream infection and colonisation of insertion site and catheter tip. What are the rates and risk factors in haematology patients?

机译：中心静脉导管相关的血液感染以及插入部位和导管尖端的定植。血液学患者的发生率和危险因素是什么？

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摘要

Skin colonisation is an important source for central venous catheter (CVC) colonisation and infection. This study intended to identify risk factors for skin colonisation prior to CVC placement (baseline colonisation) and within 10 days after CVC insertion (subsequent colonisation), for CVC-tip colonisation and for bloodstream infection (BSI). Within a randomised clinical trial, data of 219 patients with haematological malignancies and inserted CVC (with a total of 5,501 CVC-days and 4,275 days at risk) in two university hospitals were analysed. Quantitative skin cultures were obtained from the insertion site before CVC placement and at regular intervals afterwards. CVC-tip cultures were taken on CVC removal and data collection was performed. Statistical analysis included linear and logistic regression models. Age was an independent risk factor for colonisation prior to CVC placement (baseline colonisation). Independent risk factors for subsequent colonisation were baseline colonisation and male gender. High level of subsequent skin colonisation at the insertion site was a predictor of CVC-tip colonisation, and a predictor of BSI. High level of skin colonisation predicts catheter tip colonisation and possibly subsequent infection. Sustained reduction of bacterial growth at the CVC insertion site is therefore indispensable. Male patients are at particular risk for skin colonisation and may be a target population for additional insertion-site care before and during catheterisation.
机译：皮肤定植是中央静脉导管（CVC）定植和感染的重要来源。这项研究旨在确定在放置CVC之前（基线定植）和在插入CVC后10天内（随后的定植），CVC尖端定植和血流感染（BSI）的皮肤定植的危险因素。在一项随机临床试验中，分析了两家大学医院的219例血液系统恶性肿瘤和CVC插入患者（总共有5,501天CVC天和4,275天处于危险中）的数据。在放置CVC之前和之后的固定间隔从插入部位获得定量的皮肤培养物。取CVC尖端培养以去除CVC，并进行数据收集。统计分析包括线性和逻辑回归模型。年龄是在放置CVC之前定植的一个独立的危险因素（基线定植）。随后定居的独立危险因素是基线定居和男性。在插入部位随后发生的高水平皮肤定植是CVC尖端定植的预测指标，也是BSI的预测指标。高水平的皮肤定植可预测导管尖端定植，并可能随后感染。因此，在CVC插入位点持续减少细菌生长是必不可少的。男性患者的皮肤定植风险特别高，可能是在导管插入术之前和期间进行额外插入部位护理的目标人群。

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