...
首页> 外文期刊>Neuron >Parallel Social Information Processing Circuits Are Differentially Impacted in Autism
【24h】

Parallel Social Information Processing Circuits Are Differentially Impacted in Autism

机译:并行社交信息处理电路对自闭症影响差异

获取原文
获取原文并翻译 | 示例
           

摘要

Parallel processing circuits are thought to dramatically expand the network capabilities of the nervous system. Magnocellular and parvocellular oxytocin neurons have been proposed to subserve two parallel streams of social information processing, which allow a single molecule to encode a diverse array of ethologically distinct behaviors. Here we provide the first comprehensive characterization of magnocellular and parvocellular oxytocin neurons in male mice, validated across anatomical, projection target, electrophysiological, and transcriptional criteria. We next use novel multiple feature selection tools in Fmr1-KO mice to provide direct evidence that normal functioning of the parvocellular but not magnocellular oxytocin pathway is required for autism-relevant social reward behavior. Finally, we demonstrate that autism risk genes are enriched in parvocellular compared with magnocellular oxytocin neurons. Taken together, these results provide the first evidence that oxytocin-pathway-specific pathogenic mechanisms account for social impairments across a broad range of autism etiologies.
机译:None

著录项

  • 来源
    《Neuron》 |2020年第4期|共23页
  • 作者单位

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Univ Penn Dept Bioengn Philadelphia PA 19104 USA;

    Univ Penn Perelman Sch Med Cell &

    Mol Biol Grp Philadelphia PA 19104 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

    Johns Hopkins Univ Sch Med Solomon H Snyder Dept Neurosci Baltimore MD 21205 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号