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首页> 外文期刊>Neuron >Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons
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Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons

机译：通过抑制性抑制性舒张塑性在海马节奏和记忆中的凝视

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摘要

Mental experiences can become long-term memories if the hippocampal activity patterns that encode them are broadcast during network oscillations. The activity of inhibitory neurons is essential for generating these neural oscillations, but molecular control of this dynamic process during learning remains unknown. Here, we show that hippocampal oscillatory strength positively correlates with excitatory monosynaptic drive onto inhibitory neurons (E -> I) in freely behaving mice. To establish a causal relationship between them, we identified gamma CaMKII as the long-sought mediator of long-term potentiation for E -> I synapses (LTPE -> I), which enabled the genetic manipulation of experience-dependent E -> I synaptic input/plasticity. Deleting gamma CaMKII in parvalbumin interneurons selectively eliminated LTPE -> I and disrupted experience-driven strengthening in theta and gamma rhythmicity. Behaviorally, this manipulation impaired long-term memory, for which the kinase activity of gamma CaMKII was required. Taken together, our data suggest that E -> I synaptic plasticity, exemplified by LTPE -> I, plays a gatekeeping role in tuning experience-dependent brain rhythms and mnemonic function.
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  • 来源
    《Neuron》 |2021年第6期|共26页
  • 作者

    He Xingzhi; Li Jiarui; Zhou Guangjun; Yang Jing; McKenzie Sam; Li Yanjun; Li Wenwen; Yu Jun; Wang Yang; Qu Jing; Wu Zhiying; Hu Hailan; Duan Shumin; Ma Huan;

  • 作者单位

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Univ New Mexico Dept Neurosci Albuquerque NM 87131 USA;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Mental Hlth Ctr Hangzhou 310058 Peoples;

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  • 正文语种 eng
  • 中图分类 神经病学;
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