Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus

Tyden H.; Lood C.; Gullstrand B.; Joensen A.; Ivars F.; Leanderson T.; Bengtsson A. A.

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Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus

机译：促炎S100蛋白质与系统性红斑狼疮中的肾小球肾炎和抗DSDNA抗体有关

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Objectives Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8/A9, pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils (PMNs). The underlying mechanisms for increased S100A8/A9 levels and their relation to the clinical phenotype have not been carefully investigated. We assessed S100A8/A9 and S100A12 levels in SLE patient sera in relation to disease activity, clinical phenotype, presence of anti-dsDNA antibodies and ability to promote phagocytosis of necrotic cells (NCs) by PMNs.

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《Lupus》 |2017年第2期|共11页
作者
Tyden H.; Lood C.; Gullstrand B.; Joensen A.; Ivars F.; Leanderson T.; Bengtsson A. A.;
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作者单位

Lund Univ Div Rheumatol Dept Clin Sci Lund Sweden;

Lund Univ Div Rheumatol Dept Clin Sci Lund Sweden;

Lund Univ Div Rheumatol Dept Clin Sci Lund Sweden;

Lund Univ Div Rheumatol Dept Clin Sci Lund Sweden;

Lund Univ Immunol Grp Dept Expt Med Sci Lund Sweden;

Lund Univ Immunol Grp Dept Expt Med Sci Lund Sweden;

Lund Univ Div Rheumatol Dept Clin Sci Lund Sweden;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Anti-dsDNA antibodies; S100A12; S100A8; A9; SLE glomerulonephritis; systemic lupus erythematosus;

机译：抗DSDNA抗体;S100A12;S100A8;A9;SLE肾小球肾炎;全身狼疮红斑狼疮;

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1. Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus [J] . Tyden H., Lood C., Gullstrand B., Lupus . 2017,第2期

机译：促炎S100蛋白质与系统性红斑狼疮中的肾小球肾炎和抗DSDNA抗体有关
2. Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus [J] . Tyden H., Lood C., Gullstrand B., Clinical and experimental rheumatology . 2015,第3Suppla90期

机译：促炎S100蛋白质与系统性红斑狼疮中的肾小球肾炎和抗DSDNA抗体有关
3. Anti-dsDNA antibody subtypes and anti-C1q antibodies: toward a more reliable diagnosis and monitoring of systemic lupus erythematosus and lupus nephritis. [J] . Jaekell HP, Trabandt A, Grobe N, Lupus . 2006,第6期

机译：抗DSDNA抗体亚型和抗C1Q抗体：朝着更可靠的血红蛋白和狼疮肾炎的更可靠的诊断和监测。
4. Citrullinated antibodies in systemic lupus erythematosus and primary Sjogren's syndrome [C] . Hullo D., Szdke I., Szollosi I., European Congress of Immunology . 2009

机译：Systullated抗体在Systemic Lupus红斑和原发性Sjogren综合征
5. Characterisation of a Human Antibody Response that Links Cytomegalovirus Infection with Systemic Lupus Erythematosus [D] . Neo, Jacklyn Jie Ying. 2019

机译：人抗体反应的表征，其与Systemical狼疮红斑狼疮联系细胞病毒感染
6. Anti-dsDNA Antibody Isotypes in Systemic Lupus Erythematosus: IgA in Addition to IgG Anti-dsDNA Help to Identify Glomerulonephritis and Active Disease [O] . Danilo Villalta, Nicola Bizzaro, Nicola Bassi, -1

机译：系统性红斑狼疮中的抗dsDNA抗体同种型：除IgG以外的IgA IgG抗dsDNA有助于鉴定肾小球肾炎和活动性疾病
7. Anti-dsDNA antibody isotypes in systemic lupus erythematosus: IgA in addition to IgG anti-dsDNA help to identify glomerulonephritis and active disease. [O] . Villalta D, Bizzaro N, Bassi N, 2013

机译：系统性红斑狼疮中的抗dsDNA抗体同种型：除IgG以外，IgA的抗dsDNA还有助于鉴定肾小球肾炎和活动性疾病。
8. Severe Tissue Trauma Triggers the Autoimmune State Systemic Lupus Erythematosus in the MRL/++ Lupus-Prone Mouse [R] . Anam, K., Amare, M., Naik, S., 2009

机译：严重组织创伤引发mRL / ++狼疮 - 易发小鼠自身免疫状态系统性红斑狼疮

Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus

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