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首页> 外文期刊>Annals of Nutrition & Metabolism >People with Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients
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People with Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients

机译：糖耐量受损和空腹血糖受损的人同样容易患心血管疾病：一项针对2型糖尿病患者的第一度亲属的研究

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Background/Aims: To compare the cardiovascular disease (CVD) risk factors between subjects with impaired fasting glucose (IFG) and those with impaired glucose tolerance (IGT) in the first-degree relatives (FDR) of type 2 diabetic patients. Methods: A cross-sectional study, conducted between 2004 and 2006 in 1,893 (1,412 females and 481 males) FDR of type 2 diabetic outpatients of the Isfahan Endocrine and Metabolism Research Center. In all participants, blood pressure, weight, height, waist circumference, serum lipids and HbA1c were measured and a standard 75-g 2-hour oral glucose tolerance test was performed. The diagnosis of IGT, IFG and diabetes was made according to American Diabetes Association criteria. Results: Isolated IGT and isolated IFG, and both IFG and IGT were observed in 8.8%, 17.4% and 11.2% of subjects, respectively. In comparison to subjects with normal glucose levels and tolerance (control group): the mean waist circumference was significantly higher in both IFG and IGT groups; BMI, HDL-c and LDL-c in the IFG group; and triglycerides in the IGT group. The means of all studied CVD risk factors were significantly higher in the IGT+IFG group than the control group, except for blood pressure, HDL-c and HbA1c. No significant differences were found regarding CVD risk factors between IFG and IGT groups. Conclusions: The prevalence of IFG and IGT is high in FDR of type 2 diabetic patients. CVD risk factors are similar in these 2 groups and higher than in the control group. More attention should be paid to screening and treatment of this high-risk population. Copyright
机译：背景/目的：比较2型糖尿病患者一级亲属（FDR）中空腹血糖受损（IFG）与糖耐量受损（IGT）的受试者之间的心血管疾病（CVD）危险因素。方法：在2004年至2006年之间，对伊斯法罕内分泌和代谢研究中心的2型糖尿病门诊患者1,893名（1,412名女性和481名男性）FDR进行了横断面研究。在所有参与者中，测量血压，体重，身高，腰围，血清脂质和HbA1c，并进行标准的75克2小时口服葡萄糖耐量测试。 IGT，IFG和糖尿病的诊断是根据美国糖尿病协会的标准进行的。结果：分别在8.8％，17.4％和11.2％的受试者中观察到孤立的IGT和孤立的IFG，以及IFG和IGT。与具有正常血糖水平和耐受性的受试者（对照组）相比：IFG和IGT组的平均腰围均明显更高; IFG组中的BMI，HDL-c和LDL-c;和IGT组中的甘油三酸酯。除血压，HDL-c和HbA1c外，IGT + IFG组中所有研究的CVD危险因素的平均值均显着高于对照组。在IFG和IGT组之间，关于CVD危险因素没有发现显着差异。结论：2型糖尿病患者FDR中IFG和IGT的患病率较高。 CVD危险因素在这两组中相似，并且高于对照组。应更加重视对这一高危人群的筛查和治疗。版权

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