Immunothrombosis and thromboinflammation in host defense and disease

Martinod Kimberly; Deppermann Carsten

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Immunothrombosis and thromboinflammation in host defense and disease

机译：主体防御和疾病中的免疫形成和血栓炎症

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Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.

机译：血小板在血栓形成和止血之外的作用越来越被认可。今天，我们知道它们通过与天然免疫细胞直接相互作用或分泌细胞因子/趋化因子来介导炎症。在这里，我们回顾了它们在感染、败血症、中风、心肌梗死和静脉血栓栓塞中与中性粒细胞和单核细胞/巨噬细胞的相互作用。我们讨论血小板2019冠状病毒疾病的新的作用，如GPVI或GPIB，还观察血小板对中性粒细胞胞外诱捕器（NETs）形成的影响以及感染过程中的深静脉血栓形成，例如COVID-19患者。

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来源
《Platelets》 |2021年第3期|共11页
作者
Martinod Kimberly; Deppermann Carsten;
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作者单位

Katholieke Univ Leuven Dept Cardiovasc Sci Ctr Mol &

Vasc Biol Leuven Belgium;

Univ Med Ctr Hamburg Eppendorf Inst Clin Chem &

Lab Med Hamburg Germany;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
COVID-19; immunothrombosis; macrophages; myocardial infarction; nets; neutrophil extracellular traps; neutrophils; platelets; sepsis; stroke;

机译：covid-19;免疫菌;巨噬细胞;心肌梗死;网;中性粒细胞外疏水膜;中性粒细胞;血小板;脓毒症;中风;

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Immunothrombosis and thromboinflammation in host defense and disease

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