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首页> 外文期刊>Psychiatry Research. Neuroimaging >Predicting progression of amnesic MCI: The integration of episodic memory impairment with perfusion SPECT
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Predicting progression of amnesic MCI: The integration of episodic memory impairment with perfusion SPECT

机译：预测艾默地MCI的进展：灌注SPECT的整合性记忆障碍的整合

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Abstract The present study aimed at assessing if the ability to predict progression from amnesic Mild Cognitive Impairment (aMCI) to dementia is improved by considering the presence at the baseline of Single Photon Emission Computed Tomography (SPECT) perfusion abnormalities in addition to a defect of long term memory. The Episodic Memory Score (EMS), a global index which integrates results obtained in subtests of the Rey's Verbal Learning Test and the Rey-Osterrieth Figure recall, were taken into account to evaluate defects of long term memory. The study sample consisted of 42 subjects affected by aMCI, who were followed-up during a two-year period. At the final follow-up 15 subjects progressed to AD. The EMS predicted progression from aMCI to dementia with a high level of sensitivity and a lower level of specificity, but the association of neuropsychological (EMS) and SPECT data (hypoperfusion in the Posterior Cingulate Cortex) increased the accuracy in predicting conversion from aMCI to AD. The association of results obtained by aMCI patients on memory tests and perfusion SPECT may improve the accuracy in detecting subjects who will progress to dementia. The use of currently available and low-cost investigations could be advantageous in terms of public health policies. Highlights ? The severity of episodic memory impairment may predict the progression in amnesic MCI. ? MCI subjects who progress to dementia show hypoperfusion in posterior cingulate cortex. ? The combination of SPECT and neuropsychology may improve prediction of progression.
机译：摘要本研究旨在评估除了长期记忆缺陷外，单光子发射计算机断层扫描（SPECT）灌注异常基线的存在是否能提高预测从遗忘性轻度认知损伤（aMCI）到痴呆进展的能力。情景记忆评分（EMS）是一个综合了Rey的语言学习测试和Rey Osterrith图形回忆子测试结果的全局性指数，用于评估长期记忆缺陷。研究样本包括42名受aMCI影响的受试者，他们在两年内进行了随访。在最后的随访中，15名受试者进展为AD。EMS预测从aMCI进展为痴呆，具有较高的敏感性和较低的特异性，但神经心理学（EMS）和SPECT数据（后扣带回皮质灌注不足）的关联提高了预测aMCI向AD转化的准确性。aMCI患者记忆测试和灌注SPECT结果的关联可能提高检测将进展为痴呆的受试者的准确性。就公共卫生政策而言，利用现有的低成本调查可能是有利的。亮点？情节记忆损害的严重程度可以预测遗忘性MCI的进展？进展为痴呆的MCI受试者后扣带回皮质灌注不足？SPECT和神经心理学的结合可能改善对进展的预测。

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