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首页> 外文期刊>Psychiatry Research. Neuroimaging >Attempts at memory control induce dysfunctional brain activation profiles in Generalized Anxiety Disorder: An exploratory fMRI study
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Attempts at memory control induce dysfunctional brain activation profiles in Generalized Anxiety Disorder: An exploratory fMRI study

机译：内存控制的尝试诱导通用焦虑症中的功能失调脑激活曲线：探索性FMRI研究

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Abstract Suppression of aversive memories through memory control has historically been proposed as a central psychological defense mechanism. Inability to suppress memories is considered a central psychological trait in several psychiatric disorders, including Generalized Anxiety Disorder (GAD). Yet, few studies have attempted the focused identification of dysfunctional brain activation profiles when patients with Generalized Anxiety Disorders attempt memory control. Using a well-characterized behavioral paradigm we studied brain activation profiles in a group of adult GAD patients and well-matched healthy controls (HC). Participants learned word-association pairs before imaging. During fMRI when presented with one word of the pair, they were instructed to either suppress memory of, or retrieve the paired word. Subsequent behavioral testing indicated both GAD and HC were able to engage in the task, but attempts at memory control (suppression or retrieval) during fMRI revealed vastly different activation profiles. GAD were characterized by substantive hypo-activation signatures during both types of memory control, with effects particularly strong during suppression in brain regions including the dorsal anterior cingulate and the ventral prefrontal cortex. Attempts at memory control in GAD fail to engage brain regions to the same extent HC, providing a putative neuronal signature for a well-established psychological characteristic of the illness. Highlights ? GAD and controls were studied with fMRI and a memory control paradigm. ? GAD had hypo-engagement of cortical regions particularly during memory suppression. ? Anxiety appears to alter brain activation profiles during memory control.
机译：摘要通过记忆控制抑制厌恶性记忆历来被认为是一种核心的心理防御机制。无法抑制记忆被认为是包括广泛性焦虑症（GAD）在内的几种精神疾病的核心心理特征。然而，当广泛性焦虑症患者尝试记忆控制时，很少有研究试图集中识别功能失调的大脑激活模式。我们采用一种特征明确的行为范式，研究了一组成年GAD患者和匹配良好的健康对照组（HC）的大脑激活情况。参与者在成像前学习单词联想对。在功能磁共振成像中，当他们看到配对中的一个单词时，他们被指示要么抑制记忆，要么检索配对单词。随后的行为测试表明，GAD和HC都能够参与这项任务，但在功能磁共振成像期间，记忆控制（抑制或恢复）的尝试显示出截然不同的激活模式。在这两种类型的记忆控制中，GAD都表现出实质性的低激活特征，在抑制大脑区域（包括背侧前扣带回和腹侧前额叶皮层）时，其影响尤其强烈。在GAD中进行记忆控制的尝试未能在与HC相同的程度上参与大脑区域，从而为该疾病已确立的心理特征提供了一个假定的神经元特征。亮点？GAD和对照组采用功能磁共振成像和记忆控制范式进行研究？GAD对皮质区域的参与度较低，尤其是在记忆抑制期间？在记忆控制过程中，焦虑似乎会改变大脑的激活模式。

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