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首页> 外文期刊>Psychiatry Research. Neuroimaging >Sex differences in brain metabolites in anxiety and mood disorders
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Sex differences in brain metabolites in anxiety and mood disorders

机译：焦虑和情绪障碍脑代谢物的性差异

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Gender differences in mood and anxiety disorders are well-established. However, the neural basis of these differences is not clear yet, especially in terms of brain metabolism. Indeed, although several proton Magnetic Resonance Spectroscopy ( 1 1-1 MRS) investigations reported different metabolic levels in both depression and anxiety disorders, which have been also linked to symptoms severity and response to treatment, the role of gender on these differences have not been explored yet. Therefore, this study aims at investigating the role of sex in neurometabolic alterations associated with both mood and anxiety disorders. A 3T single-voxel H-1 MRS acquisition of the dorsolateral prefrontal cortex was acquired from 14 Major Depressive Disorder, 10 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD), patients and 16 healthy controls (HC). Among males, PD patients showed significantly lower GPC + PC (also observed in GAD + PD) and Glu levels compared to HC. Finally, a significant group x sex interaction effect was observed in the GPC + PC and Glu levels. We proved the presence of an association between sex and brain metabolites in anxiety spectrum.
机译：情绪障碍和焦虑症的性别差异已经得到证实。然而，这些差异的神经基础尚不清楚，尤其是在大脑代谢方面。事实上，尽管一些质子磁共振波谱（1-1 MRS）研究报告了抑郁症和焦虑症的不同代谢水平，这也与症状严重程度和治疗反应有关，但性别在这些差异中的作用尚未被探索。因此，本研究旨在调查与情绪和焦虑障碍相关的神经代谢改变中性别的作用。对14例重度抑郁症、10例广泛性焦虑症（GAD）、11例惊恐障碍（PD）、患者和16例健康对照者（HC）的背外侧前额叶皮质进行3T单体素H-1 MRS采集。在男性中，与HC相比，PD患者的GPC+PC（GAD+PD中也观察到）和Glu水平显著降低。最后，在GPC+PC和Glu水平上观察到了显著的x组性别交互效应。我们证明了焦虑谱中的性别和大脑代谢物之间存在关联。

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