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Meta-Analysis of white matter diffusion tensor imaging alterations in borderline personality disorder

机译：边缘个性障碍白质扩散张量成像改变的荟萃分析

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Borderline personality disorder (BorPD) is characterized by instability and mood dysregulation, unstable relationships and distorted self-image. Identification of underlying anatomical and physiological changes is crucial to refine current treatments and develop new ones. In this perspective, previous magnetic resonance imaging studies have highlighted alterations associated with BorPD phenotype. In particular, diffusion-weighted imaging/Diffusion tensor imaging (DWI/DTI) has identified many white matter structural alterations in individuals with this diagnosis. Although in its infancy, limiting this line of investigation is a lack of direction at the field level. Hence, the present paper aims to conduct a meta-analysis of DWI/DTI findings in individuals with a diagnosis of BorPD, testing the hypothesis that there are specific white matter alterations associated with BorPD. To this end, we performed a meta-analysis of the existing literature of DWI/DTI in BorPD representing a total of 123 individuals with BorPD and 117 Controls. Our results indicated that individuals with BorPD show regions of reduced fractional anisotropy in the corpus callosum and fornix. These results survived all jack-knife reshuffles and showed no publication bias. This suggests that alterations in these structures may contribute to psychopathology. Further, the present results lend support to extant psychological and biological models of BorPD.
机译：边缘型人格障碍（BorPD）的特点是不稳定和情绪失调，人际关系不稳定，自我形象扭曲。识别潜在的解剖和生理变化对于完善现有治疗方法和开发新的治疗方法至关重要。从这个角度来看，以前的磁共振成像研究强调了与BorPD表型相关的改变。特别是，扩散加权成像/扩散张量成像（DWI/DTI）已在该诊断个体中识别出许多白质结构改变。虽然这项调查尚处于起步阶段，但在实地一级缺乏指导，限制了这项调查。因此，本论文旨在对诊断为BorPD的个体的DWI/DTI结果进行荟萃分析，验证存在与BorPD相关的特定白质改变的假设。为此，我们对BorPD的DWI/DTI现有文献进行了荟萃分析，共有123名BorPD患者和117名对照者。我们的结果表明，患有BorPD的个体在胼胝体和穹窿中表现出减少的部分各向异性区域。这些结果在所有jack knife重组中幸存下来，并且没有发表偏倚。这表明这些结构的改变可能有助于精神病理学。此外，目前的研究结果支持了现存的BorPD心理和生物学模型。

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