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首页> 外文期刊>Psychiatry Research. Neuroimaging >Sex differences of hippocampal structure in bipolar disorder
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Sex differences of hippocampal structure in bipolar disorder

机译：双相障碍海马结构性别差异

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摘要

Although differential patterns in clinical characteristics have been consistently noted between male and female patients with bipolar disorder (BD), the effect of sex on the hippocampal structure remains unclear. To address this, the present study investigated the effects of BD and sex on the hippocampal structure, and the relationship between the hippocampal structure and cognitive performance. Morphometric and neurocognitive analyses were performed in 91 subjects (patients with BD: male/female = 33/19; normal controls: male/female = 22/17). Patients had significantly decreased left parahippocampal gyrus area and left/right hippocampal volume compared to normal controls. Within the BD group only, female patients presented with smaller right hippocampal volume than males. In the Spatial Span (SS) test (used to assess working memory capacity) and the Maze test (used to evaluate the ability to anticipate), patients demonstrated decreased performance compared to normal controls, with a significant main effect of sex. Left parahippocampal gyrus area and right hippocampal volume were positively correlated with SS and Maze in patients; moreover, right hippocampal volume predicted 17.4% of SS performance variance. These results suggest that there may be a difference between male and female patients with regard to right hippocampal volume, and that female patients may need more attention than males.
机译：尽管双相情感障碍（BD）患者的临床特征在男女之间存在差异，但性别对海马结构的影响仍不清楚。为了解决这个问题，本研究调查了BD和性别对海马结构的影响，以及海马结构与认知能力之间的关系。对91名受试者（BD患者：男/女=33/19；正常对照组：男/女=22/17）进行了形态计量学和神经认知分析。与正常对照组相比，患者的左海马旁回面积和左/右海马体积显著减少。仅在BD组，女性患者的右海马体积小于男性。在空间广度（SS）测试（用于评估工作记忆能力）和迷宫测试（用于评估预测能力）中，与正常对照组相比，患者表现出较低的表现，主要受性别的影响。患者左侧海马旁回面积和右侧海马体积与SS和迷宫呈正相关；此外，右侧海马体积预测了SS表现差异的17.4%。这些结果表明，男性和女性患者在右海马体积方面可能存在差异，女性患者可能需要比男性更多的关注。

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