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首页> 外文期刊>Psychiatry Research. Neuroimaging >Functional network connectivity alterations in schizophrenia and depression
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Functional network connectivity alterations in schizophrenia and depression

机译：精神分裂症和抑郁症的功能网络连接改变

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There is a high degree of overlap between the symptoms of major depressive disorder (MDD) and schizophrenia, but it remains unclear whether the similar symptoms are derived from convergent alterations in functional network connectivity. In this study, we performed a group independent component analysis on resting-state functional MRI data from 20 MDD patients, 24 schizophrenia patients, and 43 matched healthy controls. The functional network connectivity analysis revealed that, compared to healthy controls, the MDD and schizophrenia patients exhibited convergent decreased positive connectivity between the left and right frontoparietal control network and decreased negative connectivity between the left control and medial visual networks. Furthermore, the MDD patients showed decreased negative connectivity between the left control and auditory networks, and the schizophrenia patients showed decreased positive connectivity between the bilateral control and language networks and decreased negative connectivity between the right control and dorsal attention networks. The convergent network connectivity alterations may underlie the common primary control and regulation disorders, and the divergent connectivity alterations may enable the distinction between the two disorders. All of the convergent and divergent network connectivity alterations were relevant to the control network, suggesting an important role of the network in the pathophysiology of MDD and schizophrenia.
机译：重度抑郁症（MDD）和精神分裂症的症状之间存在高度重叠，但尚不清楚类似症状是否源于功能网络连接的趋同性改变。在这项研究中，我们对20名MDD患者、24名精神分裂症患者和43名匹配健康对照的静息状态功能性MRI数据进行了组独立成分分析。功能性网络连通性分析显示，与健康对照组相比，MDD和精神分裂症患者的左右额顶控制网络之间的正连通性降低，而左侧对照组和内侧视觉网络之间的负连通性降低。此外，MDD患者左侧控制与听觉网络之间的负连通性降低，精神分裂症患者双侧控制与语言网络之间的正连通性降低，右侧控制与背部注意网络之间的负连通性降低。趋同的网络连通性改变可能是常见的初级控制和调节障碍的基础，而发散的连通性改变可能使这两种障碍得以区分。所有趋同和发散的网络连接改变都与控制网络有关，表明网络在MDD和精神分裂症的病理生理学中起着重要作用。

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