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首页> 外文期刊>Schizophrenia research >Resting-state functional connectivity alterations in the default network of schizophrenia patients with persistent auditory verbal hallucinations
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Resting-state functional connectivity alterations in the default network of schizophrenia patients with persistent auditory verbal hallucinations

机译：患有持续性听觉幻觉的精神分裂症患者默认网络中的静息状态功能连接改变

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To understand the neural mechanism that underlies treatment resistant auditory verbal hallucinations (AVH), is still an important issue in psychiatric research. Alterations in functional connectivity during rest have been frequently reported in patients with schizophrenia. Though the default mode network (DN) appears to be abnormal in schizophrenia patients, little is known about its role in resistant AVH. We collected resting-state functional magnetic resonance imaging (R-fMRI) data with a 3 T scanner from 19 schizophrenia patients with chronic AVH resistant to pharmacological treatment, 14 schizophrenia patients without AVH and 20 healthy controls. Using seed-based correlation analysis, we created spherical seed regions of interest (ROI) to examine functional connectivity of the two DN hub regions (posterior cingulate cortex and anteromedial prefrontal cortex) and the two DN subsystems: dorsomedial prefrontal cortex subsystem and medial temporal lobe subsystem (p < 0.0045 corrected). Patients with hallucinations exhibited higher FC between dMPFC ROI and bilateral central opercular cortex, bilateral insular cortex and bilateral precentral gyrus compared to non hallucinating patients and healthy controls. Additionally, patients with hallucinations also exhibited lower FC between vMPFC ROI and bilateral paracingulate and dorsal anterior cingulate cortex. As the anterior cingulate cortex and the insula are two hubs of the salience network, our results suggest cross-network abnormalities between DN and salience systemin patients with persistent hallucinations. (C) 2014 Elsevier B.V. All rights reserved.
机译：理解抗治疗性听觉幻觉（AVH）的神经机制仍然是精神病学研究中的重要问题。精神分裂症患者经常有休息时功能连接改变的报道。尽管默认模式网络（DN）在精神分裂症患者中似乎是异常的，但对其在抗AVH中的作用知之甚少。我们使用3 T扫描仪收集了19例对药物治疗有抵抗力的慢性AVH的精神分裂症患者，14例无AVH的精神分裂症患者和20名健康对照的静息状态功能磁共振成像（R-fMRI）数据。使用基于种子的相关性分析，我们创建了感兴趣的球形种子区域（ROI），以检查两个DN枢纽区域（后扣带回皮层和前额叶前皮层）以及两个DN子系统（背侧前额叶皮层子系统和颞叶内侧叶）的功能连通性子系统（校正后的p <0.0045）。与非幻觉患者和健康对照组相比，幻觉患者在dMPFC ROI与双侧中央操作皮层，双侧岛状皮层和双侧中央前回之间的FC较高。此外，发生幻觉的患者在vMPFC ROI与双侧有顶突和背侧前扣带回皮层之间的FC也较低。由于前扣带回皮质和岛突是显着网络的两个枢纽，因此我们的结果表明，持续幻觉患者的DN和显着系统之间存在跨网络异常。 （C）2014 Elsevier B.V.保留所有权利。

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