• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Corpus callosum volumes in bipolar disorders and suicidal vulnerability
【24h】

Corpus callosum volumes in bipolar disorders and suicidal vulnerability

机译：双极性疾病和自杀漏洞中的胼calloSum卷

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reduced size of the corpus callosum (CC) has been associated with bipolar disorders and suicidality. Here, we aimed at investigating the relative independence of these associations in a large sample of patients. Two samples of males and females totaling 209 euthymic participants were recruited, including 72 patients with a major depressive disorder, 64 with bipolar disorders and 73 healthy controls. Among patients, 61 had a lifetime history of suicide attempt and 75 had none. Structural scans were acquired with 1.5 T magnetic resonance imaging. Surface-based morphometry (Freesurfer) analysis was used to compute the volumes of the CC. In the whole sample, there was a significant reduction in the volume of mid-anterior, central, and mid-posterior (all p < 0.008) CC in bipolar patients independently from suicidality, with medium effect sizes between unipolar and bipolar patients (Cohen's d between 0.46 and 0.62). In contrast, suicide attempters did not differ from non-attempters. This significant association between CC volumes and bipolar disorders was mainly found in the male sample, while a trend was found in the female sample. Within each patient group, medication had no major effect. Our study adds to the growing body of evidence linking corpus callosum alterations and bipolar disorders.
机译：胼胝体（CC）的缩小与双相情感障碍和自杀有关。在这里，我们的目的是在大量患者样本中调查这些关联的相对独立性。共招募了209名心境正常的参与者，包括72名重度抑郁症患者、64名双相情感障碍患者和73名健康对照。在这些患者中，61人一生都有自杀未遂史，75人没有自杀未遂史。结构扫描采用1.5T磁共振成像。基于表面的形态计量学（Freesurfer）分析用于计算CC的体积。在整个样本中，与自杀无关的双相患者的中前、中央和中后（均p<0.008）CC体积显著减少，单极和双相患者之间的效应大小中等（科恩氏d介于0.46和0.62之间）。相比之下，自杀未遂者与非未遂者没有区别。CC体积与双相情感障碍之间的这种显著关联主要在男性样本中发现，而在女性样本中发现了一种趋势。在每个患者组中，药物治疗均无重大影响。我们的研究补充了越来越多的证据表明胼胝体改变与双相情感障碍有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号