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首页> 外文期刊>Psychiatry Research. Neuroimaging >The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review
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The neurobiological reward system in Prolonged Grief Disorder (PGD): A systematic review

机译：长期悲伤障碍的神经生物学奖励系统（PGD）：系统审查

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摘要

Prolonged Grief Disorder (PGD) is a debilitating condition affecting between 7% and 10% of bereaved individuals. Past imaging and psychological studies have proposed links between PGD's characteristic symptoms in particular, profound yearning -and the neural reward system. We conducted a systematic review to investigate this connection. On December 19, 2019, we searched six bibliographic databases for data on the neurobiology of grief and disordered grief. We excluded studies of the hypothalamic-pituitary-adrenal (HPA) axis, animal studies, and reviews. After abstract and full-text screening, twenty-four studies were included in the final review. We found diverse evidence for the activation of several reward-related regions of the brain in PGD. The data reviewed suggest that compared to normative grief, PGD involves a differential pattern of activity in the amygdala and orbitofrontal cortex (OFC); likely differential activity in the posterior cingulate cortex (PCC), rostral or subgenual anterior cingulate cortex (ACC), and basal ganglia overall, including the nucleus accumbens (NAc); and possible differential activity in the insula. It also appears that oxytocin signaling is altered in PGD, though the exact mechanism is unclear. Our findings appear to be consistent with, though not confirmative of, conceptualizing PGD as a disorder of reward, and identify directions for future research.
机译：长期悲伤障碍（PGD）是一种使人衰弱的疾病，影响7%到10%的丧亲者。过去的影像学和心理学研究已经提出了PGD的特征性症状，尤其是深刻的渴望，与神经奖赏系统之间的联系。我们进行了一次系统的回顾来调查这种联系。2019年12月19日，我们在六个书目数据库中搜索了关于悲伤和无序悲伤的神经生物学数据。我们排除了下丘脑-垂体-肾上腺（HPA）轴的研究、动物研究和综述。经过摘要和全文筛选，24项研究被纳入最终审查。我们在PGD中发现了大脑中几个与奖励相关的区域被激活的不同证据。回顾的数据表明，与正常悲伤相比，PGD涉及杏仁核和眶额皮质（OFC）的不同活动模式；后扣带回皮质（PCC）、嘴侧或膝下前扣带回皮质（ACC）和基底节（包括伏隔核（NAc））的活动可能存在差异；脑岛可能有不同的活动。PGD中的催产素信号似乎也发生了改变，但确切机制尚不清楚。我们的研究结果似乎与将PGD概念化为奖励障碍的观点一致，但并不确定，并为未来的研究指明了方向。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2020年第1期|共19页
  • 作者

    Kakarala S. E.; Roberts K. E.; Rogers M.; Coats T.; Falzarano F.; Gang J.; Chilov M.; Avery J.; Maciejewski P. K.; Lichtenthal W. G.; Prigerson H. G.;

  • 作者单位

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Psychiat &

    Behav Sci 1275 York Ave New York NY 10065 USA;

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Psychiat &

    Behav Sci 1275 York Ave New York NY 10065 USA;

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Med Lib 1275 York Ave New York NY 10065 USA;

    Weill Cornell Med Dept Radiol 1305 York Ave New York NY 10021 USA;

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Dept Psychiat &

    Behav Sci 1275 York Ave New York NY 10065 USA;

    Weill Cornell Med Cornell Ctr Res End Of Life Care 420 E 70th St New York NY 10021 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Bereavement; Prolonged Grief Disorder (PGD); Complicated Grief (CG); Neuroimaging; Nneurobiology;

    机译：丧亲丧亲;长期悲伤障碍（PGD）;复杂的悲伤（CG）;神经影像学;肾病学;

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