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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study
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Altered cerebellar functional connectivity in remitted bipolar disorder: A resting-state functional magnetic resonance imaging study

机译：剩余双极性障碍中改变的小脑功能连通性：静态功能磁共振成像研究

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Objectives: Several recent studies have reported a strong association between the cerebellar structural and functional abnormalities and psychiatric disorders. However, there are no studies to investigate possible changes in cerebellar functional connectivity in bipolar disorder. This study aimed to examine the whole-brain functional connectivity pattern of patients with remitted bipolar disorder II, in particular in the cerebellum. Methods: A total of 25 patients with remitted bipolar disorder II and 25 controls underwent resting-state functional magnetic resonance imaging and neuropsychological tests. Voxel-wise whole-brain connectivity was analyzed using a graph theory approach: functional connectivity strength. A seed-based resting-state functional connectivity analysis was further performed to investigate abnormal functional connectivity pattern of those regions with changed functional connectivity strength. Results: Remitted bipolar disorder II patients had significantly decreased functional connectivity strength in the bilateral posterior lobes of cerebellum (mainly lobules VIIb/VIIIa). The seed-based functional connectivity analyses revealed decreased functional connectivity between the right posterior cerebellum and the default mode network (i.e. right posterior cingulate cortex/precuneus and right superior temporal gyrus), bilateral hippocampus, right putamen, left paracentral lobule and bilateral posterior cerebellum and decreased functional connectivity between the left posterior cerebellum and the right inferior parietal lobule and bilateral posterior cerebellum in patients with remitted bipolar disorder II. Conclusion: Our results suggest that cerebellar dysconnectivity, in particular distributed cerebellar–cerebral functional connectivity, might be associated with the pathogenesis of bipolar disorder.
机译：目的：最近的几项研究报告了小脑结构和功能异常与精神疾病之间的密切联系。然而，目前还没有研究调查双相情感障碍患者小脑功能连接的可能变化。本研究旨在研究缓解型双相情感障碍II患者的全脑功能连接模式，尤其是小脑。方法：对25例缓解型双相情感障碍II患者和25例对照者进行静息状态功能磁共振成像和神经心理学测试。基于体素的全脑连接性分析采用图论方法：功能连接性强度。进一步进行基于种子的静息状态功能连接性分析，以研究功能连接性强度改变的区域的异常功能连接性模式。结果：缓解型双相情感障碍II患者双侧小脑后叶（主要是VIIb/VIIIa小叶）的功能连接强度显著降低。基于seed的功能连接性分析显示，右后小脑和默认模式网络（即右后扣带回/楔前叶和右颞上回）、双侧海马、右壳核、大脑皮层和大脑皮层之间的功能连接性降低，缓解型双相情感障碍II患者的左中央旁小叶和双侧小脑后叶以及左后小脑和右顶叶下小叶和双侧小脑后叶之间的功能连接减少。结论：我们的结果表明，小脑连接不良，尤其是分布的小脑-大脑功能连接，可能与双相情感障碍的发病机制有关。

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