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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Neurocognitive predictors of long-term clinical course in bipolar disorder
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Neurocognitive predictors of long-term clinical course in bipolar disorder

机译：双相障碍长期临床课程的神经认知预测因子

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Objective: The aim of this study was to estimate whether neurocognitive deficits are predictors of the long-term clinical course of patients with bipolar disorder. Methods: A total of 76 outpatients with bipolar disorder performed a neurocognitive assessment at baseline and were followed for a period of at least 48 months. The clinical course during the follow-up period was documented by two measures: (1) number of affective episodes and (2) time spent ill. Results: Patients had lower performance than controls in the domains of verbal memory and executive functions, and they were followed-up for a mean period of 70.73 months. Global cognitive deficits (performance 1.5 standard deviations below the mean in two or more cognitive domain) were independent predictors of both hypo/manic episode density and time spent with hypo/manic symptoms during follow-up. On the contrary, no neurocognitive measure showed a relationship with depressive morbidity during follow-up. Conclusion: Our findings suggest that cognitive deficits could be useful for predicting hypo/manic morbidity in the long-term clinical course. Theoretical and clinical implications of these findings are discussed.
机译：目的：本研究的目的是评估神经认知缺陷是否是双相情感障碍患者长期临床病程的预测因素。方法：76名双相情感障碍门诊患者在基线检查时进行神经认知评估，并随访至少48个月。随访期间的临床过程通过两个指标记录：（1）情感发作次数和（2）患病时间。结果：患者在语言记忆和执行功能方面的表现低于对照组，平均随访70.73个月。总体认知缺陷（两个或更多认知领域的表现低于平均值1.5个标准差）是随访期间轻度/躁狂发作密度和轻度/躁狂症状时间的独立预测因子。相反，在随访期间，没有任何神经认知测量显示与抑郁发病率相关。结论：我们的研究结果表明，认知缺陷可能有助于预测长期临床过程中的低躁症发病率。讨论了这些发现的理论和临床意义。

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