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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Functional near-infrared spectroscopy during a decision-making task in patients with major depressive disorder
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Functional near-infrared spectroscopy during a decision-making task in patients with major depressive disorder

机译：主要抑郁症患者的决策任务中的功能近红外光谱学

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Objective: Patients with major depressive disorder tend to exhibit poorer decision-making capacity than the general population, but neurobiological evidence is lacking. Functional near-infrared spectroscopy monitors changes in oxy-haemoglobin concentration in the cerebral cortex. It may provide an objective assessment of neurophysiological responses during decision-making processes. Thus, this study investigated the effect of major depressive disorder diagnosis and severity on prefrontal cortex activity during the Iowa gambling task. Methods: Right-handed healthy controls ( n ?=?25) and patients with major depressive disorder ( n ?=?25) were matched for age, gender, ethnicity and years of education in this cross-sectional study. Functional near-infrared spectroscopy signals and the responses made during a computerised Iowa gambling task were recorded. In addition, demographics, clinical history and symptom severity were noted. Results: Compared to healthy controls, patients with major depressive disorder had reduced haemodynamic response in several cortical regions of the frontal lobe (Hedge’s g range from 0.71 to 1.52; p values range from ?0.001 to 0.041). Among patients, mean oxy-haemoglobin declined with major depressive disorder severity in the right orbitofrontal cortex (Pearson’s r ?=??0.423; p ?=?0.024). Conclusion: Haemodynamic dysfunction of the prefrontal cortex during decision-making processes is associated with major depressive disorder diagnosis and severity. These neurophysiological alterations may have a role in the decision-making capacity of patients with major depressive disorder.
机译：目的：重度抑郁症患者的决策能力往往比普通人群差，但缺乏神经生物学证据。功能性近红外光谱监测大脑皮层中氧合血红蛋白浓度的变化。它可以对决策过程中的神经生理学反应进行客观评估。因此，本研究调查了艾奥瓦赌博任务期间，重度抑郁症的诊断和严重程度对前额叶皮质活动的影响。方法：在这项横断面研究中，右利手健康对照组（n？=？25）和重度抑郁症患者（n？=？25）的年龄、性别、种族和受教育年限相匹配。记录功能性近红外光谱信号和在计算机化艾奥瓦赌博任务中做出的反应。此外，还记录了人口统计学、临床病史和症状严重程度。结果：与健康对照组相比，重度抑郁症患者额叶多个皮质区域的血流动力学反应降低（Hedge's g范围为0.71至1.52；p值范围为？0.001至0.041）。在患者中，随着右眶额皮质重度抑郁症的严重程度，平均氧合血红蛋白下降（皮尔逊r？=0.423；p？=0.024）。结论：决策过程中前额叶皮质的血流动力学功能障碍与抑郁症的诊断和严重程度有关。这些神经生理学的改变可能会影响重度抑郁症患者的决策能力。

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