Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study

Silveira Leonardo E.; Bond David J.; MacMillan Erin Leigh; Kozicky Jan-Marie; Muralidharan Kesavan; Bucker Joana; Rosa Adriane Ribeiro; Kapczinski Flavio; Yatham Lakshmi N.

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Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study

机译：双相障碍患者的海马神经化学标记术后第一款甲型发作：预期12个月质子磁共振光谱研究

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Objective: Previous studies reported decreased N-acetyl aspartate and increased Glx (the sum of glutamate plus glutamine) in bipolar disorder. Since these studies included patients at different stages of illness, it is unknown whether these changes have a causal role or a consequence of multiple episodes and treatments. The studies in early-stage bipolar disorder patients have the potential to provide answers to these issues. Therefore, we evaluated N-acetyl aspartate and Glx levels in hippocampi of first-episode bipolar disorder patients and health subjects at baseline and at 12 months, and examined the impact of episode recurrence on these measures.

机译：目的：以前的研究报道双相情感障碍患者N-乙酰天冬氨酸减少，Glx（谷氨酸加谷氨酰胺的总和）增加。由于这些研究包括处于不同疾病阶段的患者，目前尚不清楚这些变化是因果关系，还是多发性发作和治疗的结果。对早期双相情感障碍患者的研究有可能为这些问题提供答案。因此，我们在基线检查和12个月时评估了首发双相情感障碍患者和健康受试者海马中的N-乙酰天冬氨酸和Glx水平，并检查了发作复发对这些指标的影响。

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来源
《The Australian and New Zealand journal of psychiatry》 |2017年第1期|共10页
作者
Silveira Leonardo E.; Bond David J.; MacMillan Erin Leigh; Kozicky Jan-Marie; Muralidharan Kesavan; Bucker Joana; Rosa Adriane Ribeiro; Kapczinski Flavio; Yatham Lakshmi N.;
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作者单位

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

Univ British Columbia Fac Med Dept Med Div Neurol Vancouver BC Canada;

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

Hosp Clin Porto Alegre Ctr Pesquisas Expt Lab Mol Psychiat Porto Alegre RS Brazil;

Hosp Clin Porto Alegre Ctr Pesquisas Expt Lab Mol Psychiat Porto Alegre RS Brazil;

Univ British Columbia Dept Psychiat Mood Disorders Ctr Room 2C7-2255 Wesbrook Mall Vancouver;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
Bipolar disorder; first mania; spectroscopy; metabolites; hippocampus;

机译：双极障碍;第一个躁狂;光谱;代谢物;海马;

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Hippocampal neurochemical markers in bipolar disorder patients following the first-manic episode: A prospective 12-month proton magnetic resonance spectroscopy study

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