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首页> 外文期刊>The Australian and New Zealand journal of psychiatry >Neurochemical and brain functional changes in the ventromedial prefrontal cortex of first-episode psychosis patients: A combined functional magnetic resonance imaging-proton magnetic resonance spectroscopy study
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Neurochemical and brain functional changes in the ventromedial prefrontal cortex of first-episode psychosis patients: A combined functional magnetic resonance imaging-proton magnetic resonance spectroscopy study

机译：第一发作精神病患者口腔前期皮质皮质的神经化学和脑功能变化：组合功能磁共振成像 - 质子磁共振光谱研究

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摘要

Objective: Previous studies showed alterations of brain function in the ventromedial prefrontal cortex of schizophrenia patients. Also, neurochemical changes, especially GABA level alteration, have been found in the medial prefrontal cortex of schizophrenia patients. However, the relationship between GABA level in the ventromedial prefrontal cortex and brain functional activity in schizophrenia patients remains unexplored. Methods: In total, 23 drug-naive, first-episode psychosis patients and 26 matched healthy controls completed the study. The single voxel proton magnetic resonance spectroscopy data were acquired in ventromedial prefrontal cortex region, which was used as the seed region for resting-state functional connectivity analysis. The proton magnetic resonance spectroscopy data were processed to quantify the concentrations of GABA+, glutamine and glutamate, and N-acetylaspartate in ventromedial prefrontal cortex. Spearman correlation analysis was used to examine the relationship between metabolite concentration, functional connectivity and clinical variables. Pearson correlation analysis was used to examine the relationship between GABA+ concentration and functional connectivity value. Results: In first-episode psychosis patients, GABA+ level in ventromedial prefrontal cortex was higher and was positively correlated with ventromedial prefrontal cortex-left middle orbital frontal cortex functional connectivity. N-acetylaspartate level was positively correlated with positive symptoms, and the functional connectivity between ventromedial prefrontal cortex and left precuneus was negatively associated with negative symptoms of first-episode psychosis patients. Conclusion: Our results indicated that ventromedial prefrontal cortex functional connectivity changes were positively correlated with higher local GABA+ level in first-episode psychosis patients. The altered neurochemical concentration and functional connectivity provide insights into the pathology of schizophrenia.
机译：目的：以前的研究表明精神分裂症患者的前额叶腹内侧皮质的脑功能发生了改变。此外，在精神分裂症患者的内侧前额叶皮质中也发现了神经化学变化，尤其是GABA水平的变化。然而，精神分裂症患者腹内侧前额叶皮质GABA水平与大脑功能活动之间的关系尚不清楚。方法：共有23名未服用药物的首发精神病患者和26名匹配的健康对照完成了这项研究。单体素质子磁共振波谱数据采集于腹内侧前额叶皮质区域，该区域被用作静息状态功能连通性分析的种子区域。对质子磁共振波谱数据进行处理，以量化腹内侧前额叶皮质中GABA+、谷氨酰胺和谷氨酸以及N-乙酰天冬氨酸的浓度。Spearman相关分析用于检查代谢物浓度、功能连接性和临床变量之间的关系。Pearson相关分析用于检验GABA+浓度与功能连接值之间的关系。结果：在首发精神病患者中，腹内侧前额叶皮质GABA+水平较高，且与腹内侧前额叶皮质左眶中额叶皮质功能连通性呈正相关。N-乙酰天冬氨酸水平与阳性症状呈正相关，腹内侧前额叶皮质和左楔前叶之间的功能连接与首发精神病患者的阴性症状呈负相关。结论：我们的研究结果表明，在首发精神病患者中，腹内侧前额叶皮质功能连接的改变与较高的局部GABA+水平呈正相关。神经化学浓度和功能连接的改变为精神分裂症的病理学提供了见解。

著录项

  • 来源
  • 作者

    Cen Haixin; Xu Jiale; Yang Zhilei; Mei Li; Chen Tianyi; Zhuo Kaiming; Xiang Qiong; Song Zhenghua; Wang Yingchan; Guo Xiaoyun; Wang Jinhong; Jiang Kaida; Xu Yifeng; Li Yao; Liu Dengtang;

  • 作者单位

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Sch Biomed Engn Inst Med Imaging Technol 1954 Huashan Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Dept Med Imaging Sch Med Shanghai Peoples R;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

    Shanghai Jiao Tong Univ Sch Biomed Engn Inst Med Imaging Technol 1954 Huashan Rd Shanghai;

    Shanghai Jiao Tong Univ Shanghai Mental Hlth Ctr Episode Schizophrenia &

    Early Psychosis Program;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    First-episode psychosis; ventromedial prefrontal cortex; neuronal metabolites; GABA; resting-state functional connectivity;

    机译：第一集精神病;腹侧前额叶皮质;神经元代谢物;GABA;休息状态功能连接;

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