Quinomycins H1 and H2, new cytotoxic antibiotics from Streptomyces sp RAL404

Hayakawa Yoichi; Sone Risako; Aoki Haruna; Kimata Shoko

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Quinomycins H1 and H2, new cytotoxic antibiotics from Streptomyces sp RAL404

机译：喹硫菌素H1和H2，来自Streptomyces SP RAL404的新细胞毒性抗生素

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Two new cytotoxic antibiotics designated quinomycins H1 (2) and H2 (3) were isolated from the culture broth of Streptomyces sp. RAL404. The molecular formula of both compounds was established as C52H65N11O13S2 by electrospray ionization mass spectrometry (ESI-MS). Their structures were determined as echinomycin (1) derivatives containing a 3-hydoxyquinaldic acid molecule in place of one of the two quinoxaline-2-carboxylic acid chromophores. Quinomycins H1 (2) and H2 (3) showed selective cytotoxicity against RG-E1-4 cells bearing the adenovirus oncogenes with IC(50)s of 11 nM and 12 nM, respectively.

机译：从链霉菌RAL404的培养液中分离到两种新的细胞毒性抗生素，命名为喹诺mycins H1（2）和H2（3）。通过电喷雾电离质谱（ESI-MS）确定这两种化合物的分子式为C52H65N11O13S2。它们的结构被确定为棘霉素（1）衍生物，含有一个3-羟基喹醛酸分子代替两个喹啉-2-羧酸发色团中的一个。喹诺mycins H1（2）和H2（3）对携带腺病毒癌基因的RG-E1-4细胞显示出选择性细胞毒性，其IC（50）s分别为11 nM和12 nM。

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《The Journal of Antibiotics: An International Journal》 |2018年第10期|共4页
作者
Hayakawa Yoichi; Sone Risako; Aoki Haruna; Kimata Shoko;
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Tokyo Univ Sci Fac Pharmaceut Sci Dept Med &

Life Sci 2641 Yamazaki Noda Chiba 2788510 Japan;

Tokyo Univ Sci Fac Pharmaceut Sci Dept Med &

Life Sci 2641 Yamazaki Noda Chiba 2788510 Japan;

Tokyo Univ Sci Fac Pharmaceut Sci Dept Med &

Life Sci 2641 Yamazaki Noda Chiba 2788510 Japan;

Tokyo Univ Sci Fac Pharmaceut Sci Dept Med &

Life Sci 2641 Yamazaki Noda Chiba 2788510 Japan;

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正文语种 eng
中图分类药学;
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Quinomycins H1 and H2, new cytotoxic antibiotics from Streptomyces sp RAL404

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