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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Streptomyces vietnamensis GIMV4.0001: a granaticin-producing strain that can be readily genetically manipulated.
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Streptomyces vietnamensis GIMV4.0001: a granaticin-producing strain that can be readily genetically manipulated.

机译：Streptomyces越南语Gimv4.0001：产生榴芩苷的菌株，其可以容易地遗传操纵。

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摘要

Granaticin belongs to a class of aromatic polyketides, benzoisochro-manequinone antibiotics, among which actinorhodin is the most well-known member. The biosynthetic gene cluster of actinorhodin have been intensively studied and serves as a model for studying the type II polyketide synthatase (PKS) pathways. Granaticin has a similar basic skeleton but unique fine structure compared to actinorhodin (Figure 1). The opposite stereochemistry of the pyran ring and the unusual sugar attachment presented in granaticin structure has drawn much attention among chemical and biochemical researchers. The granaticin biosynthetic gene cluster (gra) was identified originally from Streptomyces violaceoruber TU22,1 and the functions of most biosynthetic genes were assigned based on sequence homology. After that, only a few functional studies have been carried out on this cluster.2"5 The functions of several gra genes remain totally unknown. Knowledge about how the production is regulated is still limited. The fact that S. violaceoruber Tii22 is recalcitrant to plasmid transformation1 has imposed a significant barrier to its study.
机译：谷氨酰胺是一类芳香族聚酮类抗生素，苯并异氯代马尼酮类抗生素，其中放线菌素是最著名的一种。放线菌素的生物合成基因簇已被深入研究，并作为研究II型聚酮合成酶（PKS）途径的模型。与放线菌素相比，石榴素具有相似的基本骨架，但具有独特的精细结构（图1）。吡喃环的相反立体化学和谷氨酰胺结构中不寻常的糖附着引起了化学和生化研究人员的广泛关注。谷氨酰胺生物合成基因簇（gra）最初是从紫红色链霉菌TU22,1中鉴定出来的，大多数生物合成基因的功能是基于序列同源性分配的。在此之后，仅对该集群进行了几项功能研究。2“5几个gra基因的功能仍然完全未知。关于其产生如何调节的知识仍然有限。紫红色链球菌Tii22对质粒转化的顽固性这一事实为其研究设置了重大障碍。

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