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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Streptomyces vietnamensis GIMV4.0001: a granaticin-producing strain that can be readily genetically manipulated.
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Streptomyces vietnamensis GIMV4.0001: a granaticin-producing strain that can be readily genetically manipulated.

机译：Streptomyces越南语Gimv4.0001：产生榴芩苷的菌株，其可以容易地遗传操纵。

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摘要

Granaticin belongs to a class of aromatic polyketides, benzoisochro-manequinone antibiotics, among which actinorhodin is the most well-known member. The biosynthetic gene cluster of actinorhodin have been intensively studied and serves as a model for studying the type II polyketide synthatase (PKS) pathways. Granaticin has a similar basic skeleton but unique fine structure compared to actinorhodin (Figure 1). The opposite stereochemistry of the pyran ring and the unusual sugar attachment presented in granaticin structure has drawn much attention among chemical and biochemical researchers. The granaticin biosynthetic gene cluster (gra) was identified originally from Streptomyces violaceoruber TU22,1 and the functions of most biosynthetic genes were assigned based on sequence homology. After that, only a few functional studies have been carried out on this cluster.2"5 The functions of several gra genes remain totally unknown. Knowledge about how the production is regulated is still limited. The fact that S. violaceoruber Tii22 is recalcitrant to plasmid transformation1 has imposed a significant barrier to its study.
机译：Granaticin属于一类芳族聚酮化合物，苯并二激烯酮抗生素，其中Actinorhodin是最着名的成员。 actinorhodin的生物合成基因簇已被强烈地研究并用作研究II型聚酮合成酶（PKS）途径的模型。与Actinorhodin相比（图1）相比，Granaticin具有类似的基本骨架但独特的细结构（图1）。瓜兰地环的相反的立体化学和麦芽素结构中呈现的不寻常的糖分附着在化学和生化研究中具有很多关注。最初来自Streptomyces violachoruber Tu22,1的麦结合生物合成基因簇（GRA）鉴定，并且基于序列同源性分配大多数生物合成基因的功能。在此之后，只有少数功能研究已经在这一集群上进行了.2“5若干GRA基因的功能仍然完全不为人知。关于生产如何监管的了解仍然有限。S. violachoruber Tii22是顽固的事实质粒转化1对其研究施加了重大障碍。

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