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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Pharmacological Management of Steroid-Induced Psychosis: A Review of Patient Cases
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Pharmacological Management of Steroid-Induced Psychosis: A Review of Patient Cases

机译：类固醇诱导精神病的药理管理：患者病例综述

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Objective: To review the efficacy and safety of medications used in the management of steroid-induced psychosis. Data Sources: A comprehensive literature search was conducted using PubMed, MEDLINE, ProQuest, and Scopus between May and October 2020 using the following search terminology: “steroid-induced psychosis” OR “corticosteroid-induced psychosis.” Study Selection and Data Extraction: Definitive cases, as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition , were included in this review. Geriatric patients >65 years of age, those with a confounding neurological condition such as a traumatic brain or spinal cord injury, or those with active malignancy were excluded. Data Synthesis: A total of 13 patient cases were included in this review, representing 8 male patients and 5 female patients. The mean age at symptom presentation was 42.5 years. Six patients presented with delusions, 5 presented with hallucinations, and 2 presented with both manifestations; 12 patients were managed with an antipsychotic, with haloperidol being the most commonly prescribed, followed by risperidone. One patient was managed with lithium and clonazepam alone. All patients returned to their psychological baseline upon the discontinuation or decreased dose of steroids in combination with Pharmacological intervention, though the time to resolution of symptoms varied significantly. No notable adverse drug events associated with treatments were reported. Conclusions: Steroid-induced psychosis is a serious adverse effect of corticosteroid therapy; however, management strategies that combine a dose reduction or elimination of steroids, in combination with an antipsychotic medication, are effective in resolving this syndrome.
机译：目的：回顾激素性精神病治疗药物的有效性和安全性。数据来源：在2020年5月至10月期间，使用PubMed、MEDLINE、ProQuest和Scopus进行了全面的文献检索，检索术语如下：“类固醇诱发精神病”或“皮质类固醇诱发精神病”研究选择和数据提取：根据《精神障碍诊断和统计手册》（第5版）的定义，确定病例包括在本综述中。年龄>65岁的老年患者、患有复杂神经疾病（如创伤性脑损伤或脊髓损伤）的患者或患有活动性恶性肿瘤的患者被排除在外。资料综合：本综述共包括13例患者，分别代表8名男性患者和5名女性患者。出现症状的平均年龄为42.5岁。6例患者出现妄想，5例出现幻觉，2例同时出现两种表现；12名患者接受了抗精神病药物治疗，氟哌啶醇是最常用的处方药，其次是利培酮。一名患者单独服用锂和氯硝西泮。所有患者在停用或减少类固醇剂量并进行药物干预后均恢复到心理基线，尽管症状缓解的时间有显著差异。未报告与治疗相关的显著不良药物事件。结论：激素性精神病是皮质类固醇治疗的严重副作用；然而，将类固醇的剂量减少或消除与抗精神病药物相结合的管理策略在解决该综合征方面是有效的。

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