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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Physical Activity and Alzheimer's Disease: A Systematic Review
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Physical Activity and Alzheimer's Disease: A Systematic Review

机译：身体活动和阿尔茨海默病：系统性评论

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摘要

The current literature includes several studies investigating the association between physical activity and risk of Alzheimer's disease (AD). The aim of this review was to systematically evaluate available evidence on this association. Medline via PubMed and CINAHL databases were searched for original English language research articles assessing the relationship between physical activity and incident AD. The review was limited to prospective observational and intervention studies. Criteria for exclusion were studies focusing on individuals with dementia, cross-sectional study design, and case reports. The quality of included studies was assessed in 5 domains of bias. Twenty-four studies met the inclusion criteria. The number of participants ranged from 176 to 5,698. Follow-up time varied from 1 to 34 years. Physical activity was inversely associated with risk of AD in most studies (n = 18). Leisure-time physical activity was particularly protective against AD, but not work-related physical activity. The risk of bias assessment showed that overall quality of evidence was moderate for 16 and low for 8 studies. Beyond all the available general recommendations for health promotion, current evidence does not allow to draw specific practical recommendations concerning the types, frequency, intensity, or duration of physical activity that may be protective against AD.
机译：目前的文献包括几项研究，调查体力活动与阿尔茨海默病（AD）风险之间的关系。本次审查的目的是系统地评估关于这种关联的现有证据。通过PubMed和CINAHL数据库检索Medline，以获取评估体力活动与偶发性AD之间关系的原始英语研究文章。该综述仅限于前瞻性观察和干预研究。排除标准包括针对痴呆症患者的研究、横断面研究设计和病例报告。纳入研究的质量在5个偏倚领域进行评估。24项研究符合纳入标准。参与人数从176人到5698人不等。随访时间从1年到34年不等。在大多数研究中，体力活动与AD风险呈负相关（n=18）。闲暇时间的体育活动对AD尤其有保护作用，但与工作相关的体育活动则没有。偏倚风险评估显示，16项研究的总体证据质量适中，8项研究的总体证据质量较低。除了所有可用的健康促进一般建议外，目前的证据不允许就可能预防AD的体力活动的类型、频率、强度或持续时间提出具体的实用建议。

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