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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Telomere Length in Healthy Adults Is Positively Associated With Polyunsaturated Fatty Acids, Including Arachidonic Acid, and Negatively With Saturated Fatty Acids
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Telomere Length in Healthy Adults Is Positively Associated With Polyunsaturated Fatty Acids, Including Arachidonic Acid, and Negatively With Saturated Fatty Acids

机译：健康成人的端粒长度与多不饱和脂肪酸呈正相关，包括花生醛酸，以及饱和脂肪酸的负面

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摘要

Lymphocyte telomere length (LTL) is a biomarker of aging that may be modified by dietary factors including fat. Red blood cell fatty acid status is a well-validated indicator of long-term dietary intake of fat from various sources. Recent findings from epidemiological studies of LTL in relation to fatty acids in red blood cells are not conclusive. The present study was carried out to investigate if red blood cell fatty acid status in 174 healthy older South Australians is associated with LTL. Lymphocyte telomere length was measured by real-time qPCR and fatty acid content in red blood cells was measured by gas chromatography. Our results indicate that the majority of saturated fatty acids and monounsaturated fatty acids are negatively associated with LTL, whereas polyunsaturated fatty acids are positively associated with LTL. Multiple regression analysis revealed that arachidonic acid (C20:4n-6) is significantly, independently, positively correlated with LTL (beta = 0.262; p = .000). The significant association of fatty acids, particularly C20:4n-6, with telomere length warrants further research.
机译：淋巴细胞端粒长度（LTL）是一种衰老的生物标志物，可能会被包括脂肪在内的饮食因素所改变。红细胞脂肪酸状态是一个经过验证的长期膳食摄入各种来源脂肪的指标。关于LTL与红细胞中脂肪酸相关的流行病学研究的最新发现尚不明确。本研究旨在调查174名健康的南澳大利亚老年人的红细胞脂肪酸状态是否与LTL有关。实时定量PCR检测淋巴细胞端粒长度，气相色谱检测红细胞脂肪酸含量。我们的结果表明，大多数饱和脂肪酸和单不饱和脂肪酸与LTL呈负相关，而多不饱和脂肪酸与LTL呈正相关。多元回归分析显示，花生四烯酸（C20:4n-6）与LTL显著、独立、正相关（β=0.262；p=0.000）。脂肪酸，尤其是C20:4n-6与端粒长度的显著相关性值得进一步研究。

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