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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition
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Impact of Age-Related Mitochondrial Dysfunction and Exercise on Intestinal Microbiota Composition

机译：年龄相关线粒体功能障碍和运动对肠道微生物群组成的影响

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Mitochondrial dysfunction is prevalent in the aging gastrointestinal tract. We investigated whether mitochondrial function in aging colonic crypts and exercise influences microbial gut communities in mice. Twelve PolgAmut/mut mice were randomly divided into a sedentary and exercise group at 4 months. Seven-aged matched PolgA+/+ mice remained sedentary throughout. Stool samples were collected at 4, 7, and 11 months, and bacterial profiling was achieved through 16S rRNA sequencing profiling. Mitochondrial enzyme activity was assessed in colonic epithelial crypts at 11 months for PolgAmut/mut and PolgA+/+ mice. Sedentary and exercised PolgAmut/mut mice had significantly higher levels of mitochondrial dysfunction than PolgA+/+ mice (78%, 77%, and 1% of crypts, respectively). Bacterial profiles of sedentary PolgAmut/mut mice were significantly different from the sedentary PolgA+/+ mice, with increases in Lactobacillus and Mycoplasma, and decreases in Alistipes, Odoribacter, Anaeroplasma, Rikenella, Parabacteroides, and Allobaculum in the PolgAmut/mut mice. Exercise did not have any impact upon gut mitochondrial dysfunction; however, exercise did increase gut microbiota diversity and significantly increased bacterial genera Mucispirillum and Desulfovibrio. Mitochondrial dysfunction is associated with changes in the gut microbiota. Endurance exercise moderated some of these changes, establishing that environmental factors can influence gut microbiota, despite mitochondrial dysfunction.
机译：线粒体功能障碍在衰老的胃肠道中普遍存在。我们研究了衰老结肠隐窝中的线粒体功能和运动是否影响小鼠肠道微生物群落。12只PolgAmut/mut小鼠在4个月时被随机分为静坐组和运动组。七只年龄匹配的PolgA+/+小鼠在整个过程中都保持久坐状态。在4个月、7个月和11个月时收集粪便样本，并通过16S rRNA测序分析实现细菌谱分析。在11个月时，对PolgAmut/mut和PolgA+/+小鼠的结肠上皮隐窝中的线粒体酶活性进行了评估。久坐和运动的PolgAmut/mut小鼠的线粒体功能障碍水平显著高于PolgA+/+小鼠（分别为78%、77%和1%的隐窝）。久坐的PolgAmut/mut小鼠的细菌特征与久坐的PolgA+/+小鼠显著不同，在PolgAmut/mut小鼠中，乳酸杆菌和支原体增加，而Alistipes、气味杆菌、厌氧菌、里肯内拉菌、副杆菌和异杆菌减少。运动对肠道线粒体功能障碍没有任何影响；然而，运动确实增加了肠道微生物群的多样性，并显著增加了粘菌属和脱硫弧菌属。线粒体功能障碍与肠道微生物群的变化有关。耐力运动缓和了其中一些变化，证明环境因素可以影响肠道微生物群，尽管存在线粒体功能障碍。

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