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首页> 外文期刊>The American Journal of Cardiology >Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices
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Relation of Body Mass Index to Outcomes in Patients With Heart Failure Implanted With Left Ventricular Assist Devices

机译：用左心室辅助装置植入心力衰竭患者的体重指数对患者结果的关系

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摘要

We aimed at characterizing the impact of low and high body mass index (BMI) on outcomes after left-ventricular assist device (LVAD) surgery and define the predictors of mortality in patients with abnormal BMI (low/high). This study was conducted in 19 centers from 2006 to 2016. Patients were divided based on their baseline BMI into 3 groups of BMI: low (BMI = 25 kg/ m(2)) (including overweight (BMI = 25 to 29.99 kg/m2), and obesity (BMI >= 30 Kg/m(2))). Among 652 patients, 29 (4.4%), 279 (42.8%) and 344 (52.8%) had a low-, normal-, and high BMI, respectively. Patients with high BMI were significantly more likely men, with more co-morbidities and more history of ventricular/supra-ventricular arrhythmias before LVAD implantation. Patients with abnormal BMI had significantly lower survival than those with normal BMI. Notably, those with low BMI experienced the worst survival whereas overweight or obese patients had similar survival. Four predictors of mortality for LVAD candidates with abnormal BMI were defined: total bilirubin >= 16 mmol/L before LVAD, hypertension, destination therapy, and cardiac surgery with LVAD. Depending on the number of predictor per patients, those with abnormal BMI may be divided in 3 groups of 1-year mortality risk, i.e., low (0 to 1 predictor: 29% and 31%), intermediate (2 to 3 predictors, 51% and 52%, respectively), and high (4 predictors: 83%). In conclusion, LVAD recipients with abnormal BMI experience lower survival, especially underweight patients. Four predictors of mortality have been identified for LVAD population with abnormal BMI, differentiating those a low-, intermediate-, and high risks of death. (c) 2020 Elsevier Inc. All rights reserved.
机译：我们旨在描述低体重指数（BMI）和高体重指数（BMI）对左心室辅助装置（LVAD）手术后结局的影响，并定义BMI异常（低/高）患者死亡率的预测因素。这项研究从2006年到2016年在19个中心进行。根据基线BMI将患者分为三组：低BMI（BMI=25kg/m2）（包括超重（BMI=25至29.99kg/m2）和肥胖（BMI>=30kg/m2））。在652名患者中，29名（4.4%）、279名（42.8%）和344名（52.8%）的BMI分别为低、正常和高。BMI高的患者更可能是男性，LVAD植入前有更多的合并症和室上/室性心律失常病史。BMI异常患者的生存率明显低于BMI正常患者。值得注意的是，低BMI患者的生存率最差，而超重或肥胖患者的生存率相似。定义了体重指数异常的LVAD候选者的四个死亡率预测因子：LVAD前总胆红素>=16 mmol/L、高血压、目的地治疗和LVAD心脏手术。根据每位患者预测因子的数量，BMI异常者可分为3组1年死亡率风险，即低（0-1预测因子：29%和31%）、中等（2-3预测因子，分别为51%和52%）和高（4预测因子：83%）。总之，体重指数异常的LVAD患者生存率较低，尤其是体重不足患者。对于体重指数异常的LVAD人群，已经确定了四个死亡率预测因子，区分了低、中、高死亡风险人群。（c） 2020爱思唯尔公司版权所有。

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