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首页> 外文期刊>Annals of Clinical and Laboratory Science: Official Journal of the Association of Clinical Scientists >Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons.
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Aluminum-induced dendritic pathology revisited: cytochemical and electron microscopic studies of rabbit cortical pyramidal neurons.

机译：铝诱导的树突状病理再探：兔皮质锥体神经元的细胞化学和电子显微镜研究。

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摘要

Intracisternal administration of aluminum maltolate induces biochemical and histological changes in the rabbit brain. The primary histological response to this aluminum intoxication is the appearance within many neuronal somata and dendrites of intensely argyrophilic masses of fibrillar material. Ultrastructural examination of these bodies in both conventionally-prepared and silver-stained sections shows them to be composed of neurofilaments. For this reason, we have elected to call these argyrophilic masses "neurofilamentous arrays (NFAs)." At their zenith, NFAs in cortical pyramidal neurons comprise thousands of filaments interconnected by periodic crossbridges. NFAs begin to be formed within both somata and dendrites as isolated groups of neurofilaments, which apparently go on to assemble en masse within the cytoplasm. In symptomatic animals, many cortical neurons are rich in NFAs, yet lack classic cytological signs of degeneration, such as nuclear pyknosis. Though silver staining reveals extensive NFAs only in aluminum-exposed brains, there is a strong degree of immunostaining for phosphorylated neurofilamentous epitopes in both untreated and Al-injected animals. This suggests that protein subunits that are already present in the neurons under normal circumstances are recruited, in the presence of aluminum, to form NFAs through the directed assembly of masses of oriented filaments.
机译：颅内注射麦芽糖酸铝可诱导兔脑的生化和组织学改变。这种铝中毒的主要组织学反应是在许多神经元的躯体和纤维状物质强烈嗜银团块的树突中出现。在常规制备的和银染的切片中对这些尸体的超微结构检查显示它们由神经丝组成。因此，我们选择将这些嗜银团称为“神经丝阵列（NFA）”。皮质锥体神经元中的NFA处于顶峰时，包含成千上万的细丝，这些细丝通过周期性的交叉桥相互连接。 NFAs在分离的神经丝组中开始在躯体和树突中形成，它们显然继续在细胞质中大量聚集。在有症状的动物中，许多皮质神经元富含NFA，但缺乏经典的细胞学变性迹象，例如核固缩。尽管银染仅在铝暴露的大脑中显示出广泛的NFA，但在未治疗和注射铝的动物中，磷酸化神经丝状表位的免疫染色程度都很高。这表明在铝的存在下，正常情况下神经元中已经存在的蛋白质亚基被募集，通过定向聚集的定向细丝团来形成NFA。

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