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首页> 外文期刊>Annals of Clinical and Laboratory Science: Official Journal of the Association of Clinical Scientists >Application of SPR Imaging Biosensor for the Measurement of 20S Proteasomes in Blood Plasma of Children with Thermal Injury
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Application of SPR Imaging Biosensor for the Measurement of 20S Proteasomes in Blood Plasma of Children with Thermal Injury

机译：SPR成像生物传感器在热损伤患儿血浆20S蛋白酶体检测中的应用

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Background. Determination of proteasome concentration in blood plasma in children with burns, with the Surface Plasmon Resonance Imaging biosensor. Material and Methods. 35 children scalded by hot water, with burns in 4-20% TBSA were included into the study (age 9 months up to 14 years, mean age 2,5+1 years). Blood plasma 20S proteasome concentration was assessed in 2-6h, 12-16h, 3d, 5d, and 7d after injury using Surface Plasmon Resonance Imaging biosensor. Results. Statistically significant elevation of circulating 20S proteasome concentration was noted in all groups 12-16 hours after the injury; however, differences were more evident in children with the more severe burns. Circulating 20S proteasome concentration in the plasma was increased until day 7 in the group with severe burns, until day 5 in the group with moderate burns and until day 3 in the group with minor burns. Circulating 20S proteasome concentration in the plasma was highly correlated with burn severity. Conclusions. The SPR imaging biosensor can be used for determination of 20S proteasome in plasma of patients with burns. Circulating 20S proteasomes are elevated after burn injury and slowly reach the normal range during the wound healing process. Increase in circulating 20S proteasome concentration is proportional to the severity of the burn injury and do not correlate with age or sex.
机译：背景。使用表面等离子体共振成像生物传感器测定烧伤患儿血浆中的蛋白酶体浓度。材料与方法。该研究纳入了35名因热水烫伤的儿童，其中TBSA烧伤率为4-20％（年龄9个月至14岁，平均年龄2.5 + 1岁）。使用表面等离子体共振成像生物传感器在受伤后2-6h，12-16h，3d，5d和7d评估血浆20S蛋白酶体浓度。结果。损伤后12-16小时，所有组中循环中20S蛋白酶体浓度的统计学上显着升高;但是，在烧伤较严重的儿童中差异更加明显。严重烧伤组血浆中循环中20S蛋白酶体的浓度一直增加到第7天，中度烧伤组直到第5天，轻度烧伤组直到第3天。血浆中循环的20S蛋白酶体浓度与烧伤严重程度高度相关。结论SPR成像生物传感器可用于测定烧伤患者血浆中的20S蛋白酶体。烧伤后循环中的20S蛋白酶体升高，并在伤口愈合过程中缓慢达到正常范围。循环中20S蛋白酶体浓度的增加与烧伤的严重程度成正比，与年龄或性别无关。

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