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首页> 外文期刊>Domestic Animal Endocrinology >Metoclopramide induces preparturient, low-level hyperprolactinemia to increase milk production in primiparous sows
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Metoclopramide induces preparturient, low-level hyperprolactinemia to increase milk production in primiparous sows

机译：甲基丙酰胺诱导预备，低水平的高催乳素血症，以增加孕母猪的牛奶产量

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Inadequate milk production by sows often limits the growth of piglets. A successful lactation requires prolactin (PRL)-induced differentiation of the alveolar epithelium within the mammary glands of sows between days 90-110 of gestation. We hypothesized that induction of late gestational hyperprolactinemia in primiparous sows by oral administration of the dopamine antagonist metoclopramide (MET) would enhance mammary epithelial differentiation, milk yield, and piglet growth rate and that these effects would carry over into a subsequent lactation. Twenty-six gilts were assigned to receive either MET (n = 13, 0.8 mg/kg) or vehicle (CON, n = 13) twice daily from days 90-110 of gestation. The same sows were followed into their second lactation without additional treatment. On day 90 of gestation, circulating PRL concentrations peaked 45 min after feeding MET (P < 0.001) and then returned to baseline 3 h later. This response occurred daily out to day 104 of gestation (P < 0.05). Compared with CON, MET-treated gilts had enlarged alveoli on gestation day 110 (P < 0.05). Treatment with MET did not affect feed intake, body weight, or body fatness during pregnancy or lactation. Piglets born to MET-treated sows had both increased body weights and average daily gain on lactation days 14 and 21 (P < 0.05). Milk intake by piglets was estimated from deuterium oxide dilution. Although milk intake by piglets nursing MET sows was not statistically different from those nursing CON sows on day 21 of lactation (P = 0.18), there was a greater increase in milk consumption by piglets born to MET-treated sows between days 9 and 21 of lactation than for those in CON litters (P < 0.001). In one group of second parity sows (n = 11) that were treated with MET during their first gestation, milk yield increased by 21% during their second lactation (P < 0.05) in association with a 14% decline in body fatness across lactation compared with a 7% decline in CON sows (P < 0.05). These findings demonstrate that MET-induced hyperprolactinemia in primiparous sows during late pregnancy can increase milk yield and piglet growth rate, setting the stage for further large-scale studies. Crown Copyright (c) 2020 Published by Elsevier Inc. All rights reserved.
机译：母猪产奶量不足通常会限制仔猪的生长。成功的哺乳需要催乳素（PRL）诱导母猪乳腺内的肺泡上皮细胞在妊娠90-110天之间分化。我们假设，通过口服多巴胺拮抗剂甲氧氯普胺（MET）在初产母猪中诱导晚期妊娠高催乳素血症将增强乳腺上皮分化、产奶量和仔猪生长速度，并且这些影响将持续到随后的哺乳期。从妊娠90-110天开始，26头母猪每天接受两次MET（n=13，0.8 mg/kg）或溶媒（CON，n=13）。同样的母猪在没有额外治疗的情况下被追踪到第二次哺乳期。在妊娠第90天，循环PRL浓度在喂食MET后45分钟达到峰值（P<0.001），然后在3小时后恢复到基线水平。这种反应每天发生在妊娠第104天（P<0.05）。与CON相比，MET处理的母猪在妊娠第110天肺泡增大（P<0.05）。在怀孕或哺乳期间，MET治疗不会影响采食量、体重或体脂。在哺乳第14天和第21天，MET处理母猪出生的仔猪体重和平均日增重均增加（P<0.05）。根据氧化氘稀释法估计仔猪的牛奶摄入量。虽然哺乳MET母猪的仔猪与哺乳CON母猪的仔猪在哺乳第21天的采奶量在统计学上没有差异（P=0.18），但在哺乳第9天至21天期间，MET处理母猪出生的仔猪的耗奶量比对照母猪出生的仔猪增加更多（P<0.001）。在一组第二产次母猪（n=11）中，在第一次妊娠期间使用MET，第二次哺乳期间产奶量增加了21%（P<0.05），与对照母猪的7%下降相比，整个哺乳期的体脂减少了14%（P<0.05）。这些研究结果表明，妊娠晚期MET诱导的初产母猪高泌乳素血症可以提高产奶量和仔猪生长速度，为进一步的大规模研究奠定了基础。皇冠版权（c）2020由爱思唯尔公司出版。保留所有权利。

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